碳酸氢钠预防造影剂肾病疗效的Meta分析.pdfVIP

摘要 摘 要 目的：评价碳酸氢钠预防造影剂肾病 （CIN ）是否优于氯化钠。 方法：采用循证医学系统评价方法，计算机检索中国生物医学文献数据库 （CBM ）、中国期刊全文数据库 （CNKI) 、维普数据库 （VIP ）、万方数据库 （Wanfang ）、PubMed 、MEDLINE 、 oogle Scholar 电子数据库，收集碳酸氢钠 水化预防 CIN 相关文献。按纳入与排除标准选择合格文献、进行质量评估、提 取有效数据，采用 STATA 12.0 软件对符合标准的文献进行 Meta 分析。 结果：共 17 篇随机对照试验被纳入研究。纳入文章的发表时间从 2002 年 至 2013 年 1 月，预防 CIN 发生的Meta 分析结果显示碳酸氢钠组 CIN 发生率显 著低于氯化钠组(RR = 0.614 ，0. 95% CI 0.399 ~ 0.944, P = 0.026) ，两组在减少肾 替代疗法及死亡比例方面无统计学差异，分别为(RR = 0.693, 95% CI 0.329 ~ 1.460，P = 0.335) ，(RR = 0.725,95% CI 0.402 ~ 1.309, P = 0.286) 。 结论：与氯化钠相比，使用碳酸氢钠水化预防可显著减少 CIN 发生风险。 关键词：碳酸氢钠；造影剂肾病；预防；Meta 分析 2 万方数据 Abstract ABSTRACT Objection ：To assess the efficacy of Sodium bicarbonate versus sodium chloride in the prevention of contrast-induced nephropathy （CIN ）. Methods：According to evidence-based medicine method of systematic review, randomized controlled trials(RCTs) about sodium bicarbonate-based hydration in prevention of CIN were retrieved from CBM, CNKI , VIP , Wangfang, PubMed, MEDLINE and oogle Scholar. The qualities of included studies were evaluated ．Data was extracted into a suitable form. At last the Meta-analysis were operated by using STATA statistical software. esult ：Fiannly all 17 RCTs from 2002 to January 2013 were included. The results of meta-analysis showed that the total incidence of CIN in Sodium bicarbonate group was