VEGFR_3与肿瘤淋巴转移的研究进展_陈浩.pdfVIP

OI :10.13431/ki.immunol.j 　 　22　3 　20066 　　IMMUNOLOGICAL JOURNAL Vol.22 No.3 June 2006 S29 [] 1000-8861(2006)03(S)-0029-04 VEGFR-3 1 1 1, 2 陈　浩, 高　媛, 孙启鸿 (1.军事医学科学院放射与辐射医学研究所免疫学研究室, 北京 100850; 2.北京蛋白质组研究中心 体工程研究室, 北京 102206) [　] 　。 , , 。 , 。 ———3(VEGFR-3)VEGF-C 。VEGFR-3。 [] 　VEGFR-3;; [ ] 　R730.3;R73-37　　　　[] 　A Progress in VEGFR-3 and cancer metastasis CHEN Hao, GAO Yuan, SUN Qi-hong (Department of Immunology , Institute of R adiation Medicine, Academy of Mili- tary Medical Sciences , Beij ing 100850, China ) [Abstract] 　Tumor metastasis is a major cause of death in cancer patients.The lymphatic system is the primary route for metastasis in most human cancer.The existence of tumor cellsin lymph nodes (LNs)is a sign that metastatic spread of cancer has occurred, and a key pro- gnosticfactor for the patient s outcome. uring the processes of cancer cells spreading, vascular endothelial growth factors (VEGFs)and their receptors (VEGFRs)play important roles.In particular, VEGFR-3 and its ligands VEGF-C andVEGF- play crucial roles in promoting lym- phatic vascular growth.This review summarized the recent data onVEGFR-3 in the tumor metastasis. [Key words] 　VEGFR-3;Tumor metastasis;Tumor therapy 　　、 VEGFR-3 。VEGFR-3 。, 。 , 、 VEGFR-3。 , 。 1 　VEGFR-3 , , (lymphangiogenesis), VEGFR-3 Flt4, 。 , (7 , )、。VEGFR-3 ves- , , sel endothelium growth factor C (VEGF-C ), 3(vessel en- , dothelium growth factor receptor 3, VEGFR-3)、 , 1(lymphaticvessel endothelial HA receptor, 。VEGFR-3 LYVE-1), , ,VEGFR-3 。, VEGF-C [1] 。, VEGFR-3 [2] 、 。, VE