塞卡病毒及其疫苗.pdfVIP

生 物 工 程 学 报 田德桥 等/寨卡病毒及其疫苗研究 1 Chinese Journal of Biotechnology /cjbcn January 25, 2017, 33(1): 1−15 DOI: 10.13345/j.cjb.160361 ©2017 Chin J Biotech, All rights reserved ·特邀综述· “ ”SARS 2014 “2015 ” Lancet Nature Nanotechnology “ ”“” “” 田德桥，陈薇 100071 , . . , 2017, 33(1): 1–15. Tian DQ, Chen W. Progress in Zika virus and its vaccines. Chin J Biotech, 2017, 33(1): 1–15. 摘 要: 寨卡病毒与黄热病毒、登革热病毒、日本脑炎病毒、西尼罗病毒等都属于蚊媒传播的黄病毒属病毒。 寨卡病毒分离于 1947 年，但由于分布区域有限，所致寨卡热症状较轻，很长一段时间并没有引起太多的关注。 最近一些年，特别是2015 年后，巴西的寨卡疫情暴发及其与新生儿小脑畸形的关联，引起了全球越来越多的 关注。疫苗是应对寨卡疫情的重要手段，目前全球有30 余个机构在进行寨卡病毒疫苗的研发。本文综述了寨 卡病毒的生物学、流行病学、临床特征以及当前不同类型寨卡病毒疫苗研发现状，同时对其他几种黄病毒属病 毒批准和临床阶段疫苗情况进行了概述，以为相关研究人员提供参考。 : 寨卡病毒，黄热病毒，登革热病毒，日本脑炎病毒，疫苗 Received: September 28, 2016; Accepted: November 8, 2016 Supported by: National Key Technologies Research and Development Emergency Program of ZIKA Epidemic Prevention and Control (2016). Corresponding author: Chen Wei. E-mail: cw0226@ “ (2016)” 2016-11-15 /kcms/detail/11.1998.Q1557.002.html 2 ISSN 1000-3061 CN 11-1998/Q Chin J Biotech January 25, 2017 Vol.33 No.1 Progress in Zika virus and its vaccines Deqiao Tian, and Wei Chen Institute of Biotechnology , Academy of Military Medical Sciences , Beijing 100071, China Abstract: Like Yellow fever virus, Dengue virus, Japanese encephalitis virus and West Nile virus, Zika virus is also a mosquito-borne flavivirus. Since it was isolated in 1947, there has been little concern over Zika virus due to its limited distribution and mild symptoms. In recent years, especially since 2015, Zika virus has become a global concern because of its outbreak in Brazil and associated microcephaly. Vaccines against Zika vir