荧光检测芯片.pdf

Pathology International 2010; 60: 543–550 doi:10.1111/j.1440-1827.2010.02561.x Review Article Fluorescence in situ hybridization analysis with a tissue microarray: ‘FISH and chips’ analysis of pathology archives pin_2561 543..550 Haruhiko Sugimura,1 Hiroki Mori,1 Kiyoko Nagura,1 Shin-ichiro Kiyose,1 Tao Hong,1 Masaru Isozaki,2 Hisaki Igarashi,1 Kazuya Shinmura,1 Akio Hasegawa,2 Yasuhiko Kitayama3 and Fumihiko Tanioka4 1Department of Pathology, Hamamamatsu University School of Medicine, Higashi-ward, Hamamatsu, 2 Department of Diagnostic Pathology and Laboratory Medicine, Odawara Municipal Hospital, Odawara, 3 Department of Pathology, International University of Health and Welfare Mita Hospital, Tokyo 4 Division of Pathology and Laboratory Medicine, Iwata City Hospital, Iwata, Japan Practicing pathologists expect major somatic genetic labourious4 that only limited information on chromosomal changes in cancers, because the morphological deviations abnormalities in human solid tumors in situ was available in the cancers they diagnose are so great that the somatic until recently. The latest methodologies that involve the use genetic changes to direct these phenotypes of tumors are of human genome information, however, have provided us supposed to be correspondingly tremendous. Several lines techniques that make it possible to identify any locus-specific of evidence, especially lines gene