Meta分析统计基础.ppt

Meta－分析的统计学基础 王洪源 北京大学公共卫生学院 流行病学与卫生统计学系why_w@ 一、 概 述 用X线进行乳腺癌筛查Mammography for breast cancer is an established screening method Is screening with mammography justifiable? Gotzsche Olsen [Nordic Cochrane Centre] conducted a systematic review in 2000 and updated it in 2001. They identified 8 large RCTs on this topic, with over 182,000 women randomized The authors found that no trial data were of high quality Two were of medium quality, and the rest were poor quality or flawed. When the results of the two medium quality trials were combined, the risk ratio was 1.00 (95% CI 0.96, 1.05) The