盐酸吡格列酮的示波极谱测定.pdfVIP

盐酸吡格列酮 的示波极谱测定 魏小平．李建平’ (桂林工学院材料与化学工程系，桂林541004) 摘要：提出了测定微量盐酸吡格列酮的示波极谱法。在氨水一NHtCl缓冲溶液中，盐酸吡格 列酮在示波板谱仪上于--1．42V处产生一灵敏的极谱还原波，导数波高与盐酸吡格列酮溶液质量 浓度在0．4～40mg·L．1范围内呈线性关系。优化了试验条件，对极谱波的行为和电极反应机理 进行了研究，并测定了片剂样品中盐酸吡格列酮的含量，结果与标示值厦高效液相色谱法测得结果 相符，测定结果的RSD(月=lo)值为3．04％。 关键词：盐酸吡格列酮；示波极谱法；测定 中围分类号：0657．14 文献标识码：A 文章编号：1001-4020(2007)11-0910-03 DeterminationofMicro-Amountsof Oscillopolarographic PioglitazoneHydrochloride WEI Xiao-ping，LIJian-ping‘ 541004，China) (DepartmentofMaterialandChemicalEngineering，GuilinGgllegeofEngineering，Guilin to thedeterminationofmlcroamountsof Abstract：Oseillopolarographyw∞applied pioglitazone in allammonieaealbufferof 8．8．asensitive reducfivewave by hyarochloridedrugs．In pH polarographie given betweenvaluesof wasobservedat一1．42V(％SCE)．Linear the 2stderivativeofpeak pioglitazone relationship concentrationof w∞obtainedinthe forthe clⅡ-lent(，，口)and pioglitmone range硝0．4—40mg·I_‘．Conditions methodofdetermination and electrochemicalbehaviorof atthe werestudiedoptimized．The ploglitazone dropping and also electrodemechanismoftheelectrodereactionwere studied．Themethodwasusedinthe mercury proposed ofa forits in withthe1abelledvalueand ehecked drug resultsconsistency also analysis pioglitazone