中药外洗联合前列腺素E1治疗糖尿病下肢动脉硬化闭塞症48例.pdfVIP

2008年1月第31卷第1期 陕 西 中 医 学 院 学 报 Jan．2008 Vo1．31 No．1 Journal of Shaanxi College of Traditional Chinese Medicine ·35· 中药外洗联合前列腺素E。治疗糖尿病 下肢动脉硬化闭塞症48例 任文英 李建民 赵丹阳 黄翠玲 刘秀萍 周国民 李 巍 孟 瑶 (北京市中西医结合医院肾病糖尿病中心，北京100039) 摘 要：目的观察中药外洗联合前列腺素E (PGE )治疗糖尿病下肢动脉硬化闭塞症的疗效。方法选择48 例糖尿病合并下肢动脉硬化闭塞症的住院患者为治疗组，用中药汤剂外洗联合前列腺素E。静点治疗2个疗程。 另选40例为对照组，单纯前列腺素E，(PGE，)治疗2个疗程。观察两组治疗前后症状和下肢动脉超声多普勒血 流动力学指标。结果治疗组有效率91 67％。对照组有效率77．5％。( =5．005，P0．05)，下肢动脉超声多 普勒血流动力学指标明显改善(P0 01或P0 05)。下肢超声强回声团短径与收缩压呈正相关，狭窄口血流 速度与血红蛋白值呈正相关。结论 中药外洗联合PGE 较单纯PGE 疗效好，能改善糖尿病合并下肢动脉硬化闭 塞症症状和下肢动脉超声多普勒血流动力学指标。 关键词：糖尿病下肢动脉硬化闭塞症；中药外洗；前列腺素E ；临床观察 中图分类号：R589．1 文献标识码：A 文章编号：1002—168X(2008)01一oo35—02 Effects of external herbs and PGE1 on treating Diabetes Leg Arteriosclerosis Obliterans Ren Wenying，Li jianmin，Zhao Danyang (Hospital of traditional Chinese medicine and west medicine，Beijing，100039，China) Abstract：Objective To observe the clinical efficacy of external herbs and PGEI on treating Diabetes Leg Arterioscle． rosis Obliterans(DIJAS0、．Method 48 patients with DIJASO were distributed randomly to the treatment group．Treating with external herbs and PGE1 for 2 courses．40 patients with DLASO were distributed randomly to the controI group Trea． ting only with PGE1 for 2 courses．we investigated the effect of the clinical symptoms and the hemodynamics of leg artery． Result the efficient radio of the treatment group iS 91、67％．the control group iS 77．5％．( =5．oo5，P0．05) two groups both improved the hemodynamics of leg artery．The short thrombus diameter of leg artery iS positive correlatived with systolic blood pressure．the blood flow of strait iS positive correlatived with haemoglobin，Conclusion external herbs and PGE1 iS superior to the PGE1．both can improve the clinical symptoms and the DIJAS0 ． KeY words：Diab