血清血管内皮生长因子及其受体水平与子宫肌瘤的相关性.pdfVIP

上海交通 大学学报 (医学版 ) Vo1．27 No．12 Dec．2007 Journal of Shanghai Jiaotong University(Medical Science) ·l475· 文章编号：0258—5898(2007)12—1475—03 ·，临床研究· 血清血管内皮生长因子及其受体水平与子宫肌瘤的相关性 钟一村。 李卫平。 丁传伟 (上海交通大学 医学院仁济医院妇产科，上海 200001) 摘 要：目的 研究子宫肌瘤患者血清血管内皮生长因子(sVEGF)及其受体(sVEGFR1和sVEGFR2)水平与子宫肌瘤的相关 性，以及作为子宫肌瘤临床检测指标的可行性。方法分别选取30例手术治疗的子宫肌瘤患者和同龄正常女性作为研究组和对 照组。采用ELISA法测定两组sVEGF及sVEGFR1、sVEGFR2含量。结果 研究组 sVEGF及 sVEGFR2含量明显高于对照组，具 有显著性差异(P0．01)；两组 sVEGFR1含量无显著性差异(P0．05)。子宫肌瘤患者sVEGF和sVEGFR2无月经周期变化 (P0．05)，sVEGFR2与子宫肌瘤数量显著正相关(P0．05)。结论 VEGF与子宫肌瘤发病相关，sVEGF和sVEGFR2可以作为 子宫肌瘤临床检测指标之一。 关键词：子宫肌瘤； 血管内皮生长因子； 受体 中图分类号：R7l1．74 文献标志码：A Relativity between serum vascular endothelial growth factor and its receptors and uterine myoma ZHONG Yi—cun，LI Wei—ping，DING Chuan—wei (Department of Obstetrics and Gynecology，Re Hospital，School of Medicine，Shanghai fiaotong University，Shanghai 200001，China) Abstract： 0bjective To study the relativity between serum vascular endothelial growth factor(sVEGF)，its receptors(sVEGFR1 and sVEGFR2)and uterine myoma． Methods Thirty hospitalized patients with uterine myoma were chosen as the study group and the other healthy women of the same age as control group．The levels of sVEGF，sVEGFR1 and sVEGFR2 of the two groups were determined by using ELISA technology． Results The levels of sVEGF and sVEGFR2 in the study group were much higher than in the control group(P0．01)．There was no significant difference between the levels of sVEGFR1 in the two groups(P0．05)．The levels of sVEGF and sVEGFR2 in women with myoma had no differences during the menstrual cycle．The level of sVEGFR2 was correlated with the number of myoma(P0．05)． Conclusion VEGF and its receptors may have a role in the pathogenesis of uterine myoma．The sVEGF and sVEGFR2 could become one of the clinical measure indicators of uterine myoma． Key words： uterine myoma； vascular endothelial growth facto