比索洛尔治疗原发性高血压有效性与安全性的Meta分析_邢建生.pdfVIP

Drug Evaluation Research 第 35 卷 第 5 期 2012 年 10 月 - 365 - • 临床评价 • 比索洛尔治疗原发性高血压有效性与安全性的Meta 分析 邢建生 宁夏医科大学总医院，宁夏 银川 750004 摘 要：目的 研究比索洛尔治疗原发性高血压的有效性及安全性。方法 应用 Meta 分析对 11 篇文献研究中比索洛尔与其 他常用抗高血压药治疗原发性高血压的有效性、安全性进行同质性检验及合并效应量的估计。结果 同质性检验的有效性： 2 2 χ ＝9.3473，df ＝10；安全性：χ ＝4.0549 ，df ＝10；P ＞0.05 。合并效应量的估计：有效性：OR 合并 95%可信区间为 1.53～3.06 。 安全性：OR 2 合并 的检验：χ ＝19.592 9，P ＜0.001 。结论 比索洛尔治疗原发性高血压的疗效总体上优于目前其他药物，而且 安全性比较无显著性差异。 关键词：比索洛尔；高血压；有效性；安全性；Meta 分析 中图分类号：R972.4 文献标志码：A 文章编号：1674 - 6376 (2012) 05 - 0365 - 04 Meta-analysis on efficacy and safety of Bisoprolol in treatment of essential hypertension XING Jian-sheng General Hospital of Ningxia Medical University, Yinchuan 750004, China Abstract: Objective To evaluate the safety and efficiency of bisoprolol in treatment of essential hypertension. Methods The homogeneity test and merging effect value estimation on the efficacy and safety of Bisoprolol and other antihypertensive drugs in the treatment of essential hypertension were carried out using Meta-analysis, which was reported in 11 research papers. Results Homogeneity test showed that the cited studies of efficacy and safety were homogenous: χ2 2 = 9.3473 (df = 10) and χ = 4.0549 (df = 10) (P 0.05). The results of merging effect value estimation were as follows: 95% confidence interval of ORmerging was 1.53—3.06. The result 2 of ORmerging test was χ = 19.592 9, P 0.001. Conclusion The effect of Bisoprolol on essential hypertension is better than that of other drugs, in addition, the safty has no significant difference between Bisoprolol and other drugs. Key wo