二维紫外相关光谱研究复方载药pmma 膜的释放过程study on the .pdf

2008 年第 66 卷 化 学 学 报 Vol. 66, 2008 第 10 期, 1265～1268 ACTA CHIMICA SINICA No. 10, 1265～1268 ·研究论文· 二维紫外相关光谱研究复方载药 PMMA 膜的释放过程 江 艳 武培怡* (复旦大学高分子科学系聚合物分子工程教育部重点实验室 上海 200433) 摘要 用紫外-可见光谱(UV-Vis spectroscopy)表征载有布洛芬(ibuprofen)和吡罗昔康(piroxicam)复方药物的聚甲基丙 烯酸甲酯(PMMA)膜在磷酸盐缓冲溶液(PBS) 中的释放过程, 观察两种药物在时间外扰下的释放情况. 随着时间的推移, 两种药物都保持了持久的释放. 同时, 通过二维紫外相关光谱(two-dimensional UV correlation spectroscopy)来进一步探 究两种药物从 PMMA 膜内释放到缓冲溶液中的先后顺序, 推断出布洛芬与 PMMA 之间形成了一定的氢键相互作用, 导致释放速度变缓. 复方载药膜的红外光谱证明了这种相互作用的存在, 验证了二维紫外相关光谱在药物缓释领域的 潜在应用价值. 关键词 布洛芬; 吡罗昔康; 聚甲基丙烯酸甲酯; 药物释放; 二维紫外相关光谱 Study on the Release Process of Drug-containing PMMA Film by Two-dimensional UV-Vis Correlation Spectroscopy JIANG, Yan WU, Pei-Yi* (Key Laboratory of Molecular Engineering of Polymers (Ministry of Education) and Department of Macromolecular Science, Fudan University, Shanghai 200433) Abstract UV-Vis spectroscopy was utilized to monitor the release process of ibuprofen and piroxicam from PMMA film in the phosphate-buffered saline (PBS). Both of the drugs maintained a continuous release process under time perturbation. Furthermore, two-dimensional UV correlation spectroscopy was applied to explore the sequence of the drug release and it was implied that hydrogen-bonding interaction was formed between ibuprofen and poly (methyl methacrylate (PMMA), which was responsible for the lower speed of release. FTIR spectra of drug-containing PMMA film confirmed the existence of the interaction and the po- tential applica