芦丁壳聚糖-海藻酸钠漂浮微囊的制备研究1.pdf

39 2 2 8 2 中草药 Chinese Traditional and Herbal Drugs 2 9 -¹ * 肖　莉, 张韵慧 ,许建辰, 晋兴华 (,300072) : ,- -, , , pH , S , , 3 6 -, h h : ; -; :R284. 2; R286. 02:A: 0253- 2670(2008)02- 0209- 04 - - Preparation of floating rutin alginate chitosan microcapsule XIAO Li, ZHANG un-hui, XU Jian-chen, JIN Xing-hua ( College of Pharmaceutical Science and Technology, T ianjin University, T ianjin 300072, China) : - Abstract Objective Using rutin as the model drug to prepare floating alginate chitosan microcapsule and investigate the feasibility of this pulsatile drug delivery system applied in Chinese materia medica. - Methods By means of complex coacervation to prepare alginate chitosan microcapsule and foaming agent to turn the microcapsule into gastric floating system and to investigate the release profile of the microcap- - . sule in v i tro and the influence of gas forming agent to the lag time of the microcapsule Results In v itro , , release the microcapsule responded to the change of pH value and the release profile showed S profile - 3 6 the lag time increased from h to h as the quantity of gas forming agent with the dosage of foamer in- . - creased Conclusion Floating alginate chitosan microcapsule is suitable to be applied in pulsatile drug de- livery system of Chinese materia medica with the desirable entrapment efficiency. : ; - ; Key w