单一曲安奈德皮损内注射及联合放疗治疗瘢痕疙瘩疗效对比探究.docVIP

单一曲安奈德皮损内注射及联合放疗治疗瘢痕疙瘩疗效对比探究【摘要】目的:比较曲安奈德皮损内注射联合放疗与单纯曲安奈德皮损内注射两种治疗瘢痕疙瘩的方法的临床疗效。方法:将瘢痕疙瘩患者分为A、B两组。A组行曲安奈德皮损内注射联合放疗：曲安奈德注射液40~80 mg，每4周注射1次，至瘢痕疙瘩变软变平，在最后一次注射后1周之内行，局部6MeV电子线外照射1600~2000cGy/4~9次/4~19天；B组行单纯曲安奈德皮损内注射，方法同A组，瘢痕疙瘩变平变软后加强1次，总共注射2~8次。结果:A、B两组总有效率分别为87.23%，79.59%；治愈率为55.32%，34.69%。经x?2检验两组治愈率有统计学差异（P＜0.05）。结论:曲安奈德皮损内注射联合放疗疗效确切，联合治疗优于单纯曲安奈德皮损内注射。 【关键词】瘢痕疙瘩；曲安奈德；皮损内注射；放射治疗 【中图分类号】R622 【文献标识码】A 【文章编号】1008-6455（2010）11-0016-02 Comparative study of therapeutic effects of Intralesional triamcinolone acetonide and Intralesional triamcinolone acetonide combined with radiotherapy Ma Liguo?1Rao Yinghui?2Zou Yuhuan?1 et al 【Abstract】Objective:To evaluate the effect of two treatment methods for keloids: intralesional injection of steroid combined with radiation and intralesional injection of steroid.Methods:Patients with keloids were divided into two groups. In group A, patients were treated with intralesional injection of 40-80mg triamcinolon, which was repeated once 4 weeks, 2-3 times in total, followed by radiotherapy with the total doses of 1600~2000cGy/4~9fr/4~19day within a week after the last injection when the lesions became flatting. In group B, patients were treated only with intralesional injection of 40-80mg triamcinolon, which was repeated once 4 weeks, 2-4 times in total. Results:For group A and B, the overall efficacy was 87.23% and 79.59% respectively (x?2=1.009, P=0.315); the recovery rate was 55.32% and 34.69% (x?2=4.127, P=0.042) respectively. There was significant difference between the recovery rate of group A and B (P＜0.05). Conclusions:It is concluded that the effect of intralesional triamcinolone acetonide combined with radiotherapy is satisfactory. 【Key words】keloid; intralesional injection; radiotherapy 瘢痕疙瘩又称瘢痕瘤，是皮肤受到创伤后形成的一种良性的结缔组织异常增生性疾病，发病机制尚未完全清楚。唐山市开滦有限责任公司医院于2004-2008年对60位瘢痕疙瘩的患者分别采用单纯曲安奈德皮损内注射与曲安奈德注射联合放疗两种综合治疗方法进行治疗，比较其疗效，现报告如下： 1资料与方法 1．1临床资料:60例患者中，男30例，女30例；年龄13～80岁。将其分为Ａ、Ｂ两组：A组30例，其中男13例，女17例，皮损47处，胸背部2