ii型固有淋巴细胞及其在变应性哮喘中的作用 - 中国细胞生物学学报.pdf

中国细胞生物学学报 Chinese Journal of Cell Biology 2017, 39(1): 12 1– 127 DOI: 10.11844/cj cb.2017.01.0113 II型固有淋巴细胞及其在变应性哮喘中的作用 刘超波 孙 俊 潘秀和 蒋雯雯 李 燕 李明才* (宁波大学医学院免疫学研究室, 宁波3152 11) 摘要 变应性哮喘是一种以慢性气道炎症和气道高反应性为特征的异质性疾病, 与白细胞 介素-4(interleukin-4, IL-4) 、IL-5和IL-13等II型辅助性T细胞(type 2 T helper cell, Th2)分泌的细胞因 子有关。II型固有淋巴细胞(type 2 innate lymphoid cells, ILC2s)是在转录因子维甲酸相关孤核受体α (retinoic acid receptor related orphan receptor α, RORα)和GATA结合因子3(GATA-binding factor 3, GATA3)控制下由骨髓中的淋巴样祖细胞发育而来。ILC2s能分泌Th2型细胞因子如IL-5和IL-13, 有 助于启动和维持II型免疫反应。近期研究表明, ILC2s在变应性哮喘中发挥着不可替代的作用。研 究ILC2s对于了解变应性哮喘的发病机制具有重要意义。该文将主要综述ILC2s的发现、发育、分 布与功能及其与变应性哮喘关系的最新进展。 关键词 变应性哮喘; II型免疫反应; II型固有淋巴细胞 Type 2 Innate Lymphoid Cells and Their Role in Allergic Asthma Liu Chaobo, Sun Jun, Pan Xiuhe, Jiang Wenwen, Li Yan, Li Mingcai* (Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, China) Abstract Allergic asthma is a heterogeneous disease characterized by chronic airway inflammation and airway hyperreactivity, in which type 2 T helper cell (Th2) cytokines interleukin (IL)-4, IL-5, and IL-13 are closely associated with the symptoms. Type 2 innate lymphoid cells (ILC2s) arise, under the control of the transcription factors retinoic acid receptor related orphan receptor α (RORα) and GATA-binding factor 3 (GATA3), from lymphoid progenitors in the bone marrow, to secrete Th2 cytokines including IL-5 and IL-13. ILC2s contribute to the initiation as well as to the maintenance of the adaptive type 2 immune response. Recent researches demonstrate that ILC2s play a key role in allergic asthma. The study of ILC2s has great significance to understand the pathogenesis of allergic asthma. This review will describe the recent progress on identification, d