基于增量制造的再生骨支架制备路径规划方法.pdfVIP

第49卷第23 期 机械工程学报 Vo 1.49 NO.23 2013 年 12 月 JOURNAL OF MECHANICAL ENG剧EERlNG Dec. 2013 DOI: 10.3901/JME.1013.13.012 基于增量制造的再生骨支架制备路径规划方法* 陈伟华刘缓缓张付华胡庆夕 (上海大学快速制造工程中心 上海 20例44) 摘要z 基于增量制造的再生骨支架制备方法在生物制造领域表现出巨大应用潜力，也越来越受到重视，其中制造路径规划方 法直接影响到制备的支架的结构特点，在很大程度上决定了后期支架的细胞培养以及组织修复效果。目前典型的面向工业以 及民用领域的增量制造工艺的路径规划方法不能完全适用于骨支架的制备，无法在得能够有效模拟细胞外基质结构特征的三 维贯通结构。针对这一问题，提出一种面向生物增量挤出成形技术的再生骨支架制备路径规划方法，将材料成形过程中出现 的尺寸变形的补偿融入到路径规划方法的设计中，能有效满足骨支架制备时对复杂外轮廓和梯度孔隙结构的需求.在此基础 上，绘出再生骨支架增量挤出成形系统的软件系统架构，实现方法及结果，并通过支架成形试验验证支架的性能，研究成果 对自主开发生物增量制造装备具有重要价值和意义。 关键词:增量制造再生骨支架路径规划挤出成形 中图分类号:四16 Q811 The Method of Path Planning for the Regenerated Bone-scaffold Preparation Based on Additive Manufacturing CHEN Weihua LIU Yuanyuan ZHANG Fuhua HU Qingxi (Rapid Manufacturing Engineering Center, Shanghai University, Shanghai 2∞斜4) Abstract: The regen町ated bone-scaffold preparation method based on additive manufacturing shows gr四t potential for application in the field ofbiologi臼1 manufacturing and has b白白 paid more and more attention to. The path planning methods directly affects the structure characteristics of the pr叩缸ed scaffold, which largely de伽mines the fmal cell culture and tissue repair effects. Currently 也e path planning methods in typical additive manufacturing for industrial and civil fields cannot be fully appJied ωthe preparation ofbone 侃affolds， and the three-dimensional structure which effectively simulates ex田cellul缸ma位ix 由ucture char部teristics cannot be obtained. To solve 也is problem, the method of path planning is proposed for biological regenerated bone scaffold PI哩paration based on additive extrusion manufacturing. The ∞mpensa创on of the material size deformation in the forming prωess is ∞nsid优ed in this meth叫， which effectively meet