奶牛重要经济性状全基因组关联分析研究进展 - 遗传.pdf

HEREDITAS (Beijing) 2012 5 , 34(5): 545―550 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2012.00545 奶牛重要经济性状全基因组关联分析研究进展 李聪, 孙东晓, 姜力, 刘剑锋, 张勤, 张沅, 张胜利 , , , 100193 产奶性状是奶牛最重要的生产性状, 随着平衡育种理念的提出和发展, 繁殖性状、体型性状、健康性状 和长寿性等功能性状也逐渐被重视并纳入育种规划中。鉴定产奶性状和功能性状主效基因或遗传标记并将之应 用于奶牛标记辅助选择可望加快遗传进展。随着高密度SNP 标记的高通量检测技术的发展, 全基因组关联分析 已成为鉴定畜禽重要经济性状基因的重要途径。文章对奶牛产奶性状和功能性状全基因组关联分析研究进展进 行综述。 产奶性状; 功能性状; 全基因组关联分析; 奶牛 Advances on genome-wide association study for economically im- portant traits in dairy cattle LI Cong, SUN Dong-Xiao, JIANG Li, LIU Jian-Feng, ZHANG Qin, ZHANG Yuan, ZHANG Sheng-Li National Engineering Laboratory for Animal Breeding , Key Laboratory of Animal Genetics, Breeding and reproduction, Ministry of Agri- culture, Department of Animal Science and Technology, China Agricultural University, Beijing 100193, China Abstract: Milk performance traits have been considered as the most important production traits. With the development of balance breeding sense, much attention has been paid to the functional traits such as reproduction, type, health and lon- gevity traits, which is put into breeding programs. Identification of major genes or genetic markers for milk production and functional traits and their applications in breeding program of dairy cattle are expected to improve the genetic progress of these traits. Occurrence of millions of SNPs in whole genome and high throughout genotyping techniques has made ge- nome-wide association study to be an important strategy to identify genes responsible for economic traits in domestic ani- mals. This paper reviewed the advances on genome-wide association study for milk production traits and functi