肾性贫血患者网织红细胞参数的变化及临床意义.pdfVIP

ModDiagnTreat 现代诊断与治疗 2008 Nov19(6) · 论 著 · 肾性贫血患者网织红细胞参数的变化及临床意义 吴惠玲，张大莲，高晓玲，高 翔，朱江贤(玉溪市人民医院检验科，云南玉溪653100) ChangesofRetculocyteParametersinRenalAnemiaPatientsandTheirClin— icalSignificance wuHui．1ing，ZHANGDa-fian，GAOXiao-ling，GAOXiang，ZHUJiang-xian(DepartmentofLaboratory， thePeople’sHospitalofYuxiCity，Yuxi653100，China) Abstract：Objecave Toprobeintothechangesandclinicalsignificanceofretculocyteparametersinrenala。 nemiapatients．Method Thereticulocytepercent(RET％)，absolutereticulocytecount(RET#)，immaturere- tieulocyterate(IRF％)，lowfluorescentreticuloeyterate(LFR)，middlefluorescentreticulocyterate(MFR) andhishfluorescentreticulocyte(HFR)weremeasuredbySysmexXE-2100hematologyanalyzerin88renal anemiapatients(including45patientstreatedwithanti—anemiadrugsand43patientsnottreatedwithanti-ane- miadurgs)nad80healthysubjects．Results ThelevelsofRet％，Ret#，IRF％，MFR％ andHFR％ inpa— tientstreatedwithanti·a·nemiadrugweresingificantlyhigherthanhtoseinpatientsnottreatedwiht anti--anemia durgsandhealthysubjects(P0．O1)；htelevelsofRet％，IRF％，MFR％ andHFR％ inuntreatedpatients weresingificantlylowerhtanhtoseinhealhtysubjects(P0．O1)．IfRet％ 1．73％ andIRF％8．99％ wel~setflsahtreshold，htespecificityofhteefficacyofanti—anemiadrugswas86．1％ and97．7％ ，htesensi- tivnywas62．2％ and53．3％ ，htepositiveforecastvalueswere82．4 ％ and96．0 ％ ，thenegativeforecast valueswere68．5％ and66．7％ ．Conclusions Th emeasurementofretculocyteparametersishelpfultoun- demtandthehyperplasticdegreeofbonemarrownadthegowht ofredbloodcellsystem．ThelevelofIRFde- creasesintheearlyperiodofrenalanemia，andthenincreasesafterthetreatmentofEPOandotheranti-anemia durg，whichdemonstratesthatEPO nadohteranti-anemiadrugareeffective． Keywords：Rephropathy；Anemia；Parametersofretculocyte；BloodAnalyzer 摘要：目的 探讨网织红细胞参数在肾性贫血治疗中的变化及临床意义。方法 采用SysmexXE-2100型自动血液分析 仪，检测88例各种肾病 (包括45例用抗贫血药治疗组和43例未用抗贫血药治疗组)和8O例正