髌骨周围烧灼对兔膝关节前方末梢神经纤维影响.pdfVIP

色的MD 值均高于SP 染色。 结论：（1）髌骨周围烧灼无法令髌骨及周围软组织减敏，更无法去神经化； （2 ）烧灼与单纯手术在伤口完全愈合后不会影响膝关节对疼痛的敏感程度；（3 ） 组织损伤后CGRP 与SP 分泌明显增多，考虑与疼痛的发生、调节、组织修复有 关；（4 ）膝关节髌骨髓质、髌骨上方滑膜、髌下脂肪垫以及内外侧髌骨支持带中 CGRP 阳性神经纤维的密度大于SP 阳性神经纤维。从本实验提供的组织学证据 不支持在TKA 术中行髌骨周围烧灼。 关键词：髌骨周围烧灼 膝前痛 全膝关节置换 伤害感受器 免疫组化 论文类型：应用基础 The Effect of Circumpatellar Electrocautery to the Nerve Endings of the Anterior Knee Structures Abstract Background Total knee arthroplasty (TKA) has been clinically applied wildly through the world while the postoperative anterior knee pain is still a main complication disturbing many doctors and postoperative patients. To reduce postoperative knee pain, some doctors try circumpatellar electrocautery. However, this technique is still controversial and a consensus has not been achieved. Objective To prove the effect of circumpatellar electrocautery on the postoperative knee pain following TKA by means of observing and measuring the nerve ending density of different groups of rabbit knees. Method A total of 36 rabbits (72 knees) were grouped into 3 labelling a, b, and c. Group a was non-operative group, group b was electrocautery group and group c was controlled group. Also the animals were divided into 5 teams according to timing. Team 0 was non-operative, team 1 was three days following operation, team 2 three weeks, team 3 three months and team 4 six months. After different interventions, all knees were harvested according to their timing and labeled with A to E based on their respective structures. ( A ：patella ，B ：Suprapatellar synovium，C ： Medial patellar retinaculum ， D ：Lateral patellar retinaculum ， E ：Infrapatellar fat pad ) Sections of all structures were stained by HE and immunohistochemistry. Calcitonin gene-related peptide (CGRP)