中药干预炎症因子防治胰岛细胞凋亡的临床探究.pdfVIP

提 要 目的：观察以健脾固本、解毒活血法为治则组成的胰复苏汤剂对糖尿病患者炎症 因子的影响及对胰岛功能恢复的临床疗效并探讨其作用机制。方法：68 例患者随机 分成两组，两组均采用常规糖尿病基础治疗，治疗组(38例)加服胰复苏，对照组(30 例)加服二甲双胍，疗程 8 周，观察治疗前后临床症状、体征和实验室检查指标的变 化，并进行相应统计学分析。结果：1.治疗组综合疗效总有效率为89.5%，对照组为 66.7%，两组间比较有显著性差异(P0.05)。2.治疗组中医症状改善总有效率为 89.47%，对照组总有效率为 60.00%，两组间比较有显著性差异(P0.05)。3.胰复苏 在降低血糖、糖化血红蛋白方面均有较好的疗效，治疗前后比较有显著性差异 (P0.01)，组间比较亦有显著性差异(P0.05)。4.胰复苏在改善血脂、血流变方面都 有较好的疗效，治疗前后比较有显著性差异(P0.01)，组间比较亦有显著性差异 (P0.05)。5.胰复苏在降低炎症因子、提高血浆胰岛素、改善胰岛细胞功能等方面均 有较好的疗效，治疗前后比较有显著性差异(P0.01)，组间比较亦有显著性差异 (P0.05)。结论：本研究丰富了中医药干预炎症因子防治胰岛细胞功能衰竭的理论内 容，肯定了胰复苏“健脾固本、解毒活血”的临床疗效，为今后深入研究奠定了基础。 关键词 健脾固本解毒活血；胰复苏；2型糖尿病；炎症因子；临床研究 Clinical Research which Chinese Medicine Interrupting Inflammatory Factors of Diabetes Mellitus Prevent and Therapy the Death of the pancreatic Islet Beta-cell Speciality： Internal Medicine of Traditional Chinese Medicine Author ： Guo Xiaohong Tutor： Prof. Xu Yunsheng Abstract Objective: To observe the clinical effection of YiFuSu (a prescription of Traditional Chinese Medicine) in the treatment of inflammatory factors and the death of the pancreatic Islet Beta-cell, and explore its functional mechanism. Methods: This study included 68 patients with Diabetes. They were further divided into two subgroups randomly, and treated with regular modern medicine (including physical exercise and controlling food) that can lower blood sugar. The treatment group (38)was treated with taking YiFuSu orally, and the control group(30) was taken Western medicine （Metformin ）orally. After two months of treatment, the changes of clinical symptom and laboratory index were examined. Results: 1.The total effection of YiFuSu in the treatment group reached at 89.5%, the effection of the contrast group reached at 66.7%,ther