figure 2 in situ ip after in vivo sirna repression of hif-1α.pptVIP

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figure 2 in situ ip after in vivo sirna repression of hif-1α.ppt

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figure 2 in situ ip after in vivo sirna repression of hif-1α

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection by Tobias Eckle, David K?hler, Rainer Lehmann, Karim C. El Kasmi, and Holger K. Eltzschig Circulation Volume 118(2):166-175 July 8, 2008 Copyright ? American Heart Association, Inc. All rights reserved. Figure 1. HIF-1 is stabilized with in situ IP. A, Murine model of cardiac IP. To study HIF-1 during myocardial IP, we performed in situ preconditioning consisting of 4 cycles of ischemia/reperfusion (5 minutes each) followed by indicated times of reperfusion. Tobias Eckle et al. Circulation. 2008;118:166-175 Copyright ? American Heart Association, Inc. All rights reserved. Figure 2. In situ IP after in vivo siRNA repression of HIF-1α. Tobias Eckle et al. Circulation. 2008;118:166-175 Copyright ? American Heart Association, Inc. All rights reserved. Figure 3. HIF-1 activator DMOG attenuates myocardial infarction. Tobias Eckle et al. Circulation. 2008;118:166-175 Copyright ? American Heart Association, Inc. All rights reserved. Figure 4. In situ IP after in vivo siRNA repression of PHD1, PHD2, or PHD3. Tobias Eckle et al. Circulation. 2008;118:166-175 Copyright ? American Heart Association, Inc. All rights reserved. Figure 5. HIF-1α in modulating cardiac adenosine levels during IP. A, C57BL/6 mice were treated with a left ventricular infusion of siRNA specific for HIF-1α (siHIF-1α) or csiR over 4 hours and exposed to IP treatment consistent of 4 cycles of 5 minutes of myocardial ischemia followed by 5 minutes of reperfusion. Tobias Eckle et al. Circulation. 2008;118:166-175 Copyright ? American Heart Association, Inc. All rights reserved. Figure 6. HIF-1 in CD73 and AR expression during IP. A through E, CD73 and AR transcript levels after IP with siRNA repression of HIF-1α. Tobias Eckle et al. Circulation. 2008;118:166-175 Copyright ? American Heart Association, Inc. All rights reserved. Figure 7. Contribution of the CD73 to HIF-dependent cardioprotection. Tobias Eckle et al. Circulation. 2008;118:166-175