血小板在炎症反应中作用的研究进展 - 海南医学.pdf

海南医学2017 年2 月第28 卷第4 期 doi:10.3969/j.issn.1003-6350.2017.04.035 ·综 述· 血小板在炎症反应中作用的研究进展 陈珵，徐侃 (上海交通大学附属第一人民医院急诊与危重病科，上海 20080) 【摘要】 血小板以往被认为在维持血管壁完整性和出凝血过程中有着重要作用。而近年来，越来越多的研究 证明，血小板在炎症中也起重要作用。受到炎症因子刺激后，血小板被激活后会释放大量的细胞因子，参与宿主抗 感染防御过程。本文就近年来血小板在炎症过程中所起作用进行简要综述。 【关键词】 血小板；炎症；血小板；活化 + 【中图分类号】R331.1 43 【文献标识码】A 【文章编号】 1003—6350(2017）04—0623—04 Research progress of the role of platelets in the inflammatory response. CHEN Cheng, XU Kan. Department of Emergency and Critical Medicine, Shanghai Jiao Tong University Affiliated First Peoples Hospital, Shanghai 200080, CHINA 【Abstract 】 All along, platelets were thought to play a very important role in maintaining the integrity of the ves- sel and the process of blood coagulation. In recent years, more and more studies have shown that platelets also play a sig- nificant role in inflammation. After stimulated by inflammatory factors, platelets were activated. Then, a large number of cytokines were released and involved in host defense against infection. In this paper, the progress of the role of platelets in the inflammatory process in recent years was briefly reviewed. 【Key words 】 Platelets; Inflammation; Platelet; Activate 血小板(platelet ，PLT)是血液有形成分之一。其来 能调节止血和凝血的生成，在出凝血过程中发挥不可 源于巨核细胞系，是最小的血细胞，也是直径2~4 μm 双 或缺的作用，但除此之外，越来越多的研究认为血小 面微凸的无核圆盘状细胞，由血小板膜(糖蛋白、磷脂)、 板同炎症反应相关，甚至参与全身炎症反应综合征。 血小板颗粒(致密颗粒、α-颗粒、溶酶体、过氧化物酶和 血小板及其产物直接或间接地参与炎症反应的发生、 线粒体)、血小板管道系统(开放管道、致密管道)和血小 发展