纳米混悬剂（Nano suspension）.docVIP

纳米混悬剂（Nano suspension） Advances in the research of nano-mixtures Author: wangyu scientific research information source: literature data taps: 531 update time: 2007-4-3 [key words] : nano suspension, sirolimus, arripitan, insulin Health website: At present, more than 40 percent of the drugs are water-soluble, which makes the potential fine varieties not to be listed or not to be effective. Therefore, it is urgent to solve the problem of low bioavailability of insoluble drugs. At present, there are some limitations of common solvents, such as solubilization, cyclodextrin and emulsion, etc., such as the presence of solvents in co-solvents, the presence of drugs in combination, etc. The cyclodextrin package has special requirements for the size of the drug molecule; The emulsion requires a higher solubility in the oil phase. In 1994, Muller and other nanosuspensions were developed to solve the above problems. The stability of surfactant is used to disperse drug particles in the water and form stable nano-colloidal dispersion by smashing or controlling the crystallization technology. Whether it is a drug that is difficult to dissolve in water or a drug that is difficult to dissolve in water and is difficult to dissolve in oil, the corresponding nano-suspension can be prepared by this method. As a kind of intermediate dosage form, nano-suspension can be further prepared for oral administration, injection or other drug dosage forms to improve drug absorption and bioavailability. Moreover, nano-suspension can improve the drug content of the preparation, especially for the oral and injection of high dosage and insoluble drugs. In addition, due to the lack of carrier and co-solvents in the prescription, the toxicity of injection to the drug is very low. Preparation characteristics The nanocomposite suspension is a pure drug, the micriform dispersed system of the drug nanoparticles. Type and base frame in the traditional sense of the nanometer system is different, nanometer su