美罗华联合CHOP方案治疗老年弥漫大B细胞性淋巴瘤临床探究.docVIP

美罗华联合CHOP方案治疗老年弥漫大B细胞性淋巴瘤临床探究【摘要】目的观察美罗华(利妥昔单抗,Rituximab)联合COTP方案化疗治疗方案治疗老年弥漫大B细胞性淋巴瘤的临床疗效和毒副反应。方法13例老年弥漫大B细胞淋巴瘤行RCHOP方案:美罗华375 mg/m?2,静脉滴注,每1个周期第1天(d1); 环磷酰胺750 mg/m?2,静脉注射,d1;表阿霉素60 mg/m?2,静脉注射,d1;长春新碱1.4 mg/m?2,静脉注射,d1;强的松100 mg,口服,d1~d5每21 d为1个周期,重复治疗。全部13例患者完成6个周期化疗后进行疗效评价,随访观察生存情况。结果总有效率(CR+PR)84.6%(11/13),1年PFS率为76.9%(10/13),1年总生存率为92.3%(12/13)。结论美罗华联合CHOP(RCHOP)方案治疗老年弥漫大B细胞淋巴瘤安全、有效。? 【关键词】弥漫大B细胞性淋巴瘤;美罗华;化疗 ?? A Study of Rituximab Combined with ECHOP Regimen for Treatmentofthe Elderly Patients with Diffuse Large B-Cell Lymphoma ZHANG Cheng-hui,REN Zhong-hai,LI Chang-sheng,et al.Oncology Department of nanyang Center Hospital,Nanyang 473000,China ? 【Abstract】ObjectiveTo evaluate the efficacy and toxicity of combination chemotherapy consisting of Rituximab and CHOP(R-CHOP)in elderly patients with diffuse large B-cell lymphoma.Methods13 patients with elderly patients with diffuse large B-cell lymphoma treated with the Rituximab and CHOP(R-CHOP)regimen.R-CHOP regimen:Rituximab 375 mg/m?2 was infused on the first day,Cyclophosphamide 750 mg/m?2 IV,Vincristine 1.4 mg/m?2 IV,and Epirubicin 60 mg/m?2 IV were administered on the first day of the chemotherapy course;Prednisone 100 mg was administered orally from the first day to the fifth day;the cycle was repeated every 21 days.All of the patients have received at least 6 chemotherapy cycles.The therapeutic effect was assessed.All patients were followed up.ResultsOverall response rate were 84.6%,The 1-year progression free and overall survial rates were 76.9%and 92.3%.ConclusionCombination chemotherapy including Rituximab and CHOP(R-CHOP)is effective and safety in treatment for elderly patients with diffuse large B-cell lymphoma.? 【Key words】 Diffuse large B-cell lymphoma;Rituximab;Chemotherapy ? 弥漫性大B细胞淋巴瘤(diffuse large B-celllymphoma,DLBCL)是最常见的一种非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)类型,占NHL的30%~40%??[1]?。做为DLBCL 治疗的标准方案CHOP方案,其5年生存率也仅为40%左右??[2]?,超大剂量化疗加自体造血干细胞移植虽然可提高生存率,但对于年老、合并其他疾病的患者来说并