益气调气法治疗糖尿病膀胱病的疗效视察.pdfVIP

提 要 目的：观察益气调气法治疗糖尿病膀胱病（DCP）的临床疗效和对糖 尿病大鼠降钙素基因相关肽（CGRP）的影响， 以揭示新治法作用靶点所在， 探讨其作用机理。 方法 ：将 60 例糖尿病膀胱病患者随机分为试验组（30 例）和对照组 （30 例），试验组采用益气调气法（加味枳术汤）治疗，对照组采用弥可 保治疗，观察两组在症状、体征及膀胱 残余尿等方面的临床疗效。实验 研究首先建立大鼠糖尿病模型，观察对糖尿病大鼠膀胱壁 CGRP 及血清 CGRP 含量的 影响。 结果 :临床观察显示益气调气法在改善症状 、体征及膀胱残余尿等方 面均优于对照组（P0.05）。动物实验表明益气调气法能增加大鼠膀胱壁 CGRP（降钙素基因相关肽）阳性面积的表达，有效预防了糖尿病膀胱病 的发生发展。 结论 ：益气调气法对 DCP 有良好的疗效，值 得临床推广,其作用机制 可能是增加了膀胱感觉神经递质 CGRP 的含量。 关键词 糖尿病膀胱病；益气调气；临床/实验研究 Observation of The Effect of Suppplementing Qi and Regulating Qi on Diabetic cystopathy Speciality: Internal Medieine of TCM Author:Li Qian Tutor:Professor Zhao Quanlin Abstract Objective: investigate clinical effectiveness of Suppplementing Qi and Regulating Qi for DiabeticCystopathy (DCP) and effect of CGRP of the diabetic rats, to uncover new method of the target time and explore the role of the mechanism. Method ：60 patients were divided randomly into experimental group(30 patients) and control group(30 patients),experimental group were therapied by Suppplementing Qi and Regulating Qi , control group were therapied by Mecobalamin,to observe the clinical effect of the symptoms and signs and the remainder urine of the bladder of two groups . The experimental research established model of diabetic rats firstly , to observe bladder CGRP and serum CGRP. Result: The clinical effectiveness of Suppplementing Qi and Regulating Qi on the improvement of symptoms and signs and remainder urineof the bladder than control group （ p 0.05 ）. Animal experiment indicate that the Suppplementing Qi and Regulating Qi increased positive expressions of area of bladder CGRP and of content of serum CGRP ,effective prevented ffectivly of DCP