舒天宁颗粒治疗偏头痛的疗效及血浆ET-1水平的相关性研究.pdf

提 要 目的：观察舒天宁颗粒治疗偏头痛的临床疗效，探讨治疗前后头痛指数变化与血 浆内皮素(ET-1)浓度变化的相关性，并分析头痛指数与体重指数的相关性。方法： 将 60 例无先兆偏头痛患者随机分为舒天宁颗粒治疗组和复方羊角胶囊对照组，治疗 28 天。观察治疗前后患者头痛指数、伴发症状、体重指数、血浆内皮素(ET-1)水 平，探讨头痛指数改变和各项指标的相关性，并通过头痛日记分析舒天宁颗粒治疗无 先兆偏头痛起效时间上的优势。结果：经统计学分析，治疗组总有效率 90．00％，对 照组总有效率 86．67％，两组比较总有效率有显著性差异(PO．05)。治疗组对伴随 症状、体征均有改善作用(PO．05)，对照组对心烦易怒和眩晕有改善作用(PO．05)， 对其他伴随症状没有改善作用，治疗组优于对照组(PO．01)。同时，治疗组起效时 间上具有显著优势(PO．01)。舒天宁颗粒能显著降低血浆 ET-1 浓度(PO．01)。结 论：本文立足于中医理论深入探讨头风病发病机制，为舒天宁颗粒提供理论基础和临 床证据，并验证了舒天宁颗粒通过降低血浆缩血管物质 ET-1 而发挥疗效，起效时间 具有显著优势。 关 键 词 舒 天 宁 颗 粒 ； 无 先 兆 偏 头 痛 ； 头 痛 日 记 ； 内 皮 素 - 1 ；相 关 性 Research on the Correlation Between the Effectiveness of Shutianning Granule for Migraine and the Plasma Endothelin(ET-l) Level Speciality: Internal Medicine of TCM Author: Cheng Yan Tutor: Chief Physician Hu Zhiqiang Abstract Objective: To observe the clinical effect of Shutianning Granule on Migraine,also to explore the correlation between variation of headache index and concentration of blood plasma ET-1, and the correlation between headache and weight index.Method: 60 migrainous patients without aura were divided into two groups,i.e. the treated group treated with Shutianing Granule and the control group treated with composite Yangjiao capsule with a 28 days treatment period. The headache index, concomitant symptoms, weight index, and blood plasma ET-1 levels were observed before and after therapy. Results: The treated group had a total effective rate of 90.00%, compared with the total effective rate of