补肾疏肝汤治疗肾虚肝郁型围绝经期综合征的临床探究.pdfVIP

提 要 目的：观察补肾疏肝汤治疗肾虚肝郁型围绝经期综合征的临床疗效，并探讨其作 用机制。方法：选择 50 例围绝经期综合征患者，临床研究用自身前后对照的研究方 法，观察分析治疗前后临床症状改善情况，并分别测定雌二醇（E2 ）、促卵泡生成激 素（FSH）、促黄体生成激素（LH）、β-内啡肽（β-EP）、白介素-2（IL-2）、血 清过氧化脂质（LPO）、甲状旁腺激素（PTH）、降钙素（CT），比较其治疗前后的变 化情况。结果：研究表明，治疗后与治疗前相比患者临床症状有明显改善，临床总有 效率为98.28％，Kupperman 评分有非常显著性差异（P0.01），治疗后患者血清 FSH、 LH 水平较治疗前下降（P0.05），E 水平较治疗前升高（P0.05）；β-EP、血清 IL-2 2 水平较治疗前升高（P0.05）；LPO、PTH 水平明显下降（P0.05）；CT 明显升高（P0.05）。 结论：补肾疏肝汤对治疗围绝经期综合征作用较好，能有效缓解潮热汗出、烦躁易怒、 失眠等不适症状，其作用机制是通过从整体上调整神经内分泌免疫网络而实现的。该 研究为治疗围绝经期综合征提供了宝贵的经验和线索。 关键词 补肾疏肝汤；肾虚肝郁；围绝经期综合征；临床研究 1 The Clinical Study of Treating Peripheral Menopause Syndrome (PMS) With the Decoction of Bu- Shen-Shu-Gan Speciality：Gynecology of TCM Tutor：Pro. LvMei Author ：YueYan Abstract Objective: To study the therapeutical effect of the decoction of Bu- Shen-Shu-Gan on peripheral menopause syndrome (PMS), and to explore its action mechanism. Methods: We selected 50 patients with PMS, observe the clinical symptoms improvement after treatment and detect the concentrition of E2 、FSH 、LH 、β-EP、IL-2、LPO 、PTH 、CT in the blood. Results: The clinical symptoms are significantly improved and the clinical total efficiency is 98.28%.The improvement of Kupperman scores is very significant (P0.01). After treatment, the concentrition of FSH, LH in the blood is lowered, while the concentrition of E2 in the blood is raised (P0.05). The concentrition of β-EP、IL-2 is significantly raised after treatment (P0.05). The LPO 、 PTH is remarkblely reduced ，and CT is raised(P0 ．05) Conclusions: The decoction of Bu- Shen-Shu-Gan has definitely therapeutical effect on PMS