解毒化瘀颗粒治疗大鼠急性肝衰竭的实验探究.pdfVIP

OOOO01 888960825557111 IIIIIIlllIIIll werewaswithwaswitllwerewithwaswerewerewitllwithwitllwerewithAcuteWasWasABSTRACTWistarmodelsmediummodelmodelmodelmodelmodelminusBloodD—GaINbloodbloodbloodDetoxificationFailurebloodbloodbloodbeforePentobarbitalaaTNF-ct．hundredhoursratrateratsratsThehowresearchratsLPSanGranuleratsnormalOneon3acuteacuteaortaRatsO．9％saltandandSPFafteratofofof0．1ofofofofof0．033009offofofaffects8mlafternormalnormal220ofofofandStasisandforfunctiontotodeath3concentrationconcentrationandandandandandandandandandandanesthesia．Serumandandfailureectedexecutedtreatedthetreatedectedenterocoeliatakendetoxificationdivideddistilledcutfailurethetothethethethethetotal．InthethetheSodiumstasissuchselectedstasissmallstasisstasissolutionstasisstoredsixliverliverintoinfusionin1111inducedinduceinintervalisolated1-2ml1％concentration werewhenwhenwithwaswithwithwithALFAcutemedium4used．DetoxificationbloodPHGFPHGFbloodbloodbloodbloodbloodhadhasratsrateratsrateratsratshadreducedreduceresultsLiverreducedratsonacuteacuteacuteoutandandandalsoandandandcanofofofofofofofofandandofofofofofofandforfailuretentodetoxificationcorrelateddosedosedetoxificationcausedandfromfixedfailureeachtissuetissue．Theseendotoxin．deathcoulddetoxificationdecreasedemonstratedetoxificationexamination．thatthethethatthethethethethethethethethethattheeffectsshowedsurvivalstasisstatisticalstasisstasisstasisstasisserumstatisticalstasisserumliversliverliverlevelliverinlobesliverlevelliver1indexes liverliverliverliver 111 Plus8TOSHIBATBA一1OHAUSOLYMPUS 91 Plus 表1成模后36h存活率观察结果 注：与模型组比较zxpO．05，AzxpO．01。 3．3解毒化瘀颗粒对急性肝衰竭大鼠肝功能的影响 果(见表2)。模型组明显高于正常组，差异有统计学意义(P0．05)；与 模型组比较，PHGF组、小剂量组、中剂量组、大剂量组较模型组均低， 颗粒中、高剂量组较PHGF组低，差异有统计学意义俨0．05)。提示促 肝细胞生长素、解毒化瘀颗粒低、中、高剂量组均能降低急性肝衰竭大