解毒汤治疗热毒内蕴型IgA肾病的临床探究.pdfVIP

提 要 目的：观察解毒汤治疗热毒内蕴型IgA 肾病的临床疗效，探讨中西医结合治疗本 病的优势，为进一步改良及推广配方打下基础。 方法：本研究收集热毒内蕴型IgA 肾病患者60例，随机分为2组，治疗组、对照组 各30例。对照组给予抗感染、降压、降脂、抗凝等西医基础治疗，治疗组在西医基础 治疗上加用解毒汤，2个月后观察患者临床症状、体征及实验室检查指标的变化，并 对症状及体征进行量化评分，判定其疗效。 结果：从中医量化评分来看，治疗组显效率为60%，有效率为20% ，总有效率为 80%；对照组显效率为36.7%、有效率为20% ，总有效率为56.7%，治疗组总有效率高 于对照组，统计学有显著性差异（P ＜0.05 ）。治疗组用药后积分与用药前积分相比 具有显著的统计学意义（P ＜0.01 ）。治疗前后两组尿红细胞计数、24h尿蛋白定量比 较，P值均小于0.05，具有统计学意义。比较两组患者治疗后临床疗效，治疗组愈显 率为50.0%，总有效率为86.67%；对照组愈显率为26.67% ，总有效率为66.67%，两组 比较有统计学意义（P ＜0.05 ）。两组治疗后对肾功能无明显影响。 结论：解毒汤治疗热毒内蕴型 IgA 肾病，能显著减少患者尿红细胞计数及 24h 尿蛋白定量，改善患者血尿、咽喉肿痛、口干咽燥等症状，显示出解毒汤治疗本病的 优势，是否有助于提高原发性 IgA 肾病的远期疗效有待大样本的进一步研究。 关键词 解毒汤；原发性IgA 肾病；热毒内蕴型 Clinical Study on idiopathic IgA nephropathy of heat toxin accumulating inside with Jie-du Decoction Speciality: Kidney Disease,Nephropathy Medicine of TCM Auher:Luo Caihui Tutor:Prof.Mi Jie Abstract Objective: To investigate the effect of Jie-du Decoction treating idiopathic IgA nephropathy of heat toxin accumulating inside on the basis of western medicine treatment. To explore the advantages and feasibility of combining traditional Chinese and western medicine treating idiopathic IgA nephropathy and lay the foundation for further improver promotion formula . Methods: 60 patients with idiopathic IgA nephropathy of heat toxin accumulating inside were divided into 2 groups at random, each group is 30 cases. The control group were treated with basic medicine, such as anti-infection step-down lipid-lowering and anticoagulant .while the experimental treatment group were treated with basic medicine and Jie-du Decoction. The course of treatment is 2 months. We would observe the subjects of laborary examination before and after experiment, recorded the change of patients clinical symptoms,then