防哮颗粒对哮喘缓解期儿童免疫调节的机理探究.pdfVIP

提 要 目的：本文从理论及临床方面对儿童哮喘缓解期的病因病机和防治方药进行了系 统观察与探讨，探讨中药对调节哮喘缓解期儿童机体免疫及控制气道炎症的作用机 制，揭示药物的疗效机理。方法：将60例哮喘缓解期儿童随机分为3组，分别给予防 哮颗粒（中药治疗组）、固本咳喘片（中药对照组）及酮替芬加万适宁（西药对照组） 口服，观察患儿用药前后主要症状、体征、发作次数、肺循环的变化，及防哮颗粒对 患儿免疫功能的影响，并与对照组比较。结果：防哮颗粒的总有效率为90.00%，在改 善患儿主要症状、体征，减少感冒次数、咳喘天数、肺循环方面优于两对照组，并能 减少血中嗜酸性粒细胞 (EOS)含量，提高血清中免疫因子IgA、IgG、IgM水平及CD 、 3 CD 含量，提高血液中红细胞C 受体花环率（RBC-C RR），降低红细胞免疫复合物花 8 3b 3b 环率（RBC-ICR）。结论：防哮颗粒通过控制气道慢性炎症和降低气道高反应性，增 强患儿免疫力，改善肺循环障碍，达到防治本病的目的。 关键词 防哮颗粒；儿童哮喘缓解期；临床研究 Clinical Studies on The Immunity Regulate’s Mechanism of Children’s Bronchial Asthma in Catabasis with Fang Xiao Granule Specialty:Respiratory Disease,Pediatrics Medicine of TCM Author:Yu Ninghan Tutor:Professor Xing Xianghui Abstract Objective:By observing and probing into the etiology 、pathogenesis 、prevention and cure medicine of children’s bronchial asthma in theories and clinic, we try to find efficient medication of children’s bronchial asthma in catabasis, and discuss the the immunity regulate’s mechanism and mechanism against inflammation. Methods:60 bronchial asthma children in catabasis are randomly divided into 3 groups,treated with Fang Xiao Granule (FXG) 、Gu Ben Ke Chuan Pian and Ketotifen add Wan Shi Ning. We observe the change of the children’s cardinal symptom, objective sign, frequency ，pulmonary circulation, and the influence on immunological function between three groups. Result: The clinical study shows that the total effective rate of FXG is 90.00%. FXG is better than two comparison groups in reducing cardinal symptom, objective sign, cold number of times, coughing and gasping number of days and improvin