69例子宫黏膜下富于细胞平滑肌瘤的临床病理分析.pdfVIP

， 实用医技杂志 2008年7月第l5卷第2O期 JPMT，July．2008，Vo1．15，No．20 ·2591· 69例子宫黏膜下富于细胞‘平滑肌瘤的临床病理分析 王夷黎 ，房惠琼 ，李启明 (1．佛山市妇幼保健院，广东佛山 528000； 2．佛山市中医院，广东佛山528000) 【摘 要】目的：探讨子宫黏膜下富于细胞平滑肌瘤(CellularLeimyoma，CL)的临床病理特征和生物学特性。方 法：收集69例子宫黏膜下CL的临床和病理资料。随机抽取同时期子宫普通平滑肌瘤40例作为对照，采用sP法进 行ER、PR、l(i．67和 免疫组化染色。结果：子宫黏膜下CL临床表现下腹胀痛，月经量增多，经期延长。组织学可分 为富于细胞平滑肌瘤和高度富-t-m／l~平滑肌瘤(HighCellularLeimyoma，HCL)／~种类型，平均核分裂像分别为(0～4) 个／10HPF 7i(2~5)个／10HPF。两组l(i．67、P53阳性均 ％，无明显差异，黏膜下富于细胞组的ER、PR阳性表达较 普通平滑肌瘤强，0．01P0．05。结论：子宫黏膜下CL及HCL细胞丰富，可见核分裂像及细胞核轻度异型性，仍属良 性肿瘤，预后良好。 【关键词】子宫黏膜下；富于细胞平滑肌瘤；病理学；临床 f中圈分类号】R738．7 f文献标识码】A【文章编号】1671-5098(2008)20-2591-02 Uterine Celluar Leiomyoma Arising Below Mucous Membrane：a Clinic opaflmlogi~d Anal~is 0f69 Ca8o8 WANG Yi一1P,FANG Hui—qiong2．LI Qi—ming2 ( ．Foshan Maternity and C Health,care Hospital,Foshan,Guangdong 528000,China； ZFoshan Hospital ofTraditional Chinese Medicine，Foshan,Cuangdona’528000,China) I~ametObjective To investigate the clinicopathological and biological features of the uterine cdluar leiomyoma aris~ from below mucous membrane．Methods Clinical and pathological data of 69 patients of the uterine celluar leiomy- oma arising from below mucous membrane were analyzed．40 patients ofconventional uterine leiomyoma were randomly se- lected as contro1．Immunohistochemical staining for ER、PR、Ki。67 and was carried out with the SP method．Results Cel- luar leiomyoma below mucous membrane ofuterine has menorrhagia、bradymenorrhea or gas-pain ofinferior belly’as clini- cal manifestation．It Call be devided to cellular leimyoma and high cellular leimyoma in micranatomy，both express slig