45岁以下人群颈动脉粥样硬化病变的筛查和危险因素分析.pdfVIP

生鱼旦 日第5卷第6期 Chin J Cembmv~e Dis，June．18．2008．Vo1．5．Nn 6 · 25l· 临 床 研 究 · 45岁以下人群颈动脉粥样硬化病变的 筛查和危险因素分析 王玉华 孙伟景 朱淑敏 韩凌 摘要：目的 利用彩色多普勒血流显像(CDFI)分析45岁以下人群早期颈动脉粥样硬化 (CAS)的检出率及危险因素。 方法 对25～34岁和35～44岁两个年龄组各459例的体检人员行 颈动脉超声检查，测量双侧颈总动脉远段、颈动脉分叉处及颈内动脉起始段内一中膜厚度(IMT)和 是否存在粥样硬化斑块，以IMT增厚与否分为病变组(CAS组)和正常组。并对两组的危险因素进 行比较 结果 ①cAs组l17例，平均年龄(41±5)岁；正常组801例，平均年龄(36±5)岁，两组年 龄比较，差异有统计学意义(P0．05或P0．O1)。②CAS组高血压、高脂血症、高血糖、肥胖发生 率分别为23．1％、24．8％、16．2％和34．2％；正常组为l5．1％，13．2％，8．7％和21．1％，两组比较差 异均有统计学意义。③25～34岁组CAS检出率为5．23％(24／459)，35～44岁组为20．26％(93／ 459)，两组比较差异有统计学意义(P0．01)。发生CAS患者中，25～34岁组病变程度较轻，全部 为单纯IMT增厚，而35～44岁组则有2O．4％(19／93)已形成粥样斑块(P0．05)。 结论 与25～ 34岁组比较，35～44岁年龄组CAS颈动脉粥样硬化病变发生率高、程度重；CDFI可以为45岁以下 人群颈动脉脉粥样硬化的早期诊治和预防提供客观依据。 关键词：超声检查，多普勒，彩色；颈动脉疾病；早期诊断；青年 中图分类号： R445．1；R743 文献标识码：A Screening of carotid atherosclerosis in a population less than 45 years of age using color Doppler ultrasonography and the analysis of major risk factors WANG Yu—hua ，SUN Wei-jing，ZHU Shu— min，HAN Ling． Department ofUltrasonography，Heze Municipal Hospital，Heze 274031，China Corresponding author：SUN Wei-jing，Email：workswj@163．corn Abstract：Objective To analyze the detection rate and risk factors of early carotid atherosclemsis (CAS)in a population less than 45 years of age by using color Doppler flow imaging(CDFI)． Methods Carotid uhrasonography was performed in 459 subjects from 25 to 34 years and 459 subjects from 35 to 44 years．The intima—media thickness(IMT)of distal segments of bilateral common carotid teries，carotid bifurcation and the origin of the internal carotid artery，as well as the atherosclemtic plaque were measured．The patients were divided into CAS group and normal group according to whether they had ITM thickening．and their major risk factors were investigated and analyzed Results ~)There were 1 17 patients in t