正交试验优化珠芪复肝颗粒的制粒工艺.pdf

·88· Chinese Journal of Information on TCM May 2015 Vol.22 No.5 正交试验优化珠芪复肝颗粒的制粒工艺 1 2 1 李彩东 ,梁云 ,张伟 1.兰州市第二人民医院肝病研究所,甘肃 兰州 730046；2.兰州市肺科医院药剂科,甘肃 兰州 730046 摘要：目的 优化珠芪复肝颗粒成型工艺。方法 运用正交试验设计,以颗粒各参数作为判定依据,优化浸 膏密度、辅料种类及用量、润湿剂浓度等条件,以确定最佳条件。结果 优选辅料比例为淀粉∶微晶纤维素＝3 ∶2, 浸膏相对密度为 1.20,浸膏粉与辅料用量为 1 ∶1,80%乙醇作为润湿剂进行制备。成品具有较好的流动性,临界 相对湿度为 67%。结论 本法所制颗粒各项参数均较满意,性质稳定,不易返潮,制备工艺简便可行。 关键词：正交设计；珠芪复肝颗粒；工艺条件 DOI：10.3969/j.issn.1005-5304.2015.05.024 中图分类号：R283.5 文献标识码：A 文章编号：1005-5304(2015)05-0088-03 Optimization of Preparation Technology of Zhuqi Fugan Granules by Orthogonal 1 2 1 Experiment LI Cai-dong , LIANG Yun , ZHANG Wei (1.Institute of Liver Diseases, the Second People's Hospital of Lanzhou, Lanzhou 730046, China ；2.Department of Pharmacy, Lanzhou Tuberculosis Hospital, Lanzhou 730046, China) Abstract ：Objective To optimize the formative technology for Zhuqi Fugan Granules. Methods By using orthogonal experiment design, and setting parameters of granules as determination standards, concrete density, excipient types and dosage, and consentration of wetting agent were optimized to determine the optimal conditions. Results The optimal forming technology was as follows：The optimal ratio of starch to micrite cellulose was 3 ∶2；the optimal density of extration was 1.20 ；the ratio of concrete to excipient was 1 ∶1；the optimal concentration of wetting agent was 80% of ethyl alcohol. Zhuqi Fugan Granule enjoyed good mobility and with a critical relative humidity of 67%. Conclusion Parameters of Zhuqi Fugan Granules prepared by this method are satisfying, with stable properties and low moisture absorbtion. This preparation technology is