g蛋白信号转导调节蛋白(rgs)研究进展 - 中国农学通报.pdfVIP

中国农学通报 2014,30(6):248-253 Chinese Agricultural Science Bulletin G 蛋白信号转导调节蛋白(RGS)研究进展 朱小彬，朱 霞，于一帆，陈 云 （扬州大学生物科学与技术学院，江苏扬州225009 ） 摘 要：G 蛋白信号转导导调节蛋白(RGS)是G 蛋白信号转导通路中的负性调节因子，近年来，G 蛋白信 号转导途径一直是生物领域的研究热点之一。本研究总结了近年来RGS 蛋白在动物和植物方面的研 究进展，归纳了RGS 蛋白的结构和分类；从RGS 蛋白的GAPs 作用、整合各种G 蛋白信号系统、支架蛋白 和调节细胞内运输等方面介绍了RGS 蛋白的功能；阐述了RGS 蛋白磷酸化、脂类修饰和RGS 降解等调 节机制，对RGS 蛋白的深入研究有利于对信号通路的深入了解。 关键词：RGS 蛋白；G 蛋白；负性调节因子；信号转导 中国分类号：S188 文献标志码：A 论文编号：2013-1149 Advances of Research on Regulators of G Protein Signaling (RGS Proteins) Zhu Xiaobin, Zhu Xia, Yu Yifan, Chen Yun (CollegeofBioscienceandBiotechnology,YangzhouUniversity, Yangzhou Jiangsu 225009) Abstract: Regulators of G protein signaling (RGS proteins) is a negative regulator in the G protein-mediated signaling. Recently, researches were focused on G proteins and RGS proteins. This review summarized investigative progress in animals and plant in recent years. The structure and categories were described detailed. The functions including acting as GAPs, integration G protein signaling, scaffolding protein and regulating cell transportation were analyzed. The regulatory mechanism of RGS protein was introduced from the aspect of phosphorylation, lipidmodification, degradation of RGS proteins and so on. Deep research of the RGS protein was conducive to know more about the signaling pathway. Key words: RGS protein; G protein; negative regulators; signaling 0 引言 体），包含7 个跨膜区域。配体结合在GPCR 的活性部 在生长发育过程中，生物体不断地受到外界环境 位，导致GPCR 构象的改变，导致GPCR 构象的改变并 的刺激，这些外界信号被细胞表面的受体接受后，转变 使Gα亚基与βγ二聚体解离，促进Gα亚基的GDP 转换 为细胞内信号，最终引起胞内的生理生化响应，适应环 为GTP，使信号在胞内进行传递。解离的具有活性的 境的变化。生物体内负责识别、感知、转导外