(bmp-2) and vascular calcification - 临床与病理杂志.pdfVIP

临床与病理杂志 2014, 34(5) 622 J Clin Path ol R e s doi: 10.3978/j.issn.2095-6959.2014.05.033 /articles/664 骨形态发生蛋白2(BMP-2)诱导血管钙化相关机制的新进展 李岚，刘江华，祖旭宇，伍莹 综述 (南华大学附属第一医院，湖南 衡阳 421001) [摘　要] 研究表明血管钙化是一个类似成骨的主动、可预防和可逆转的高度可调控的生物学过程。骨形 态发生蛋白 ( bone mor phogenetic proteins ，BMPs) 家族作为转化生长因子 β (transforming grow th f ac to r- β ，TG F- β ) 超家族的成员，因具有诱导骨形成的特点而得名，到目前为止，已发现 3 0 余 种BMP 成员, 其中 BMP-2 是一类唯一能够单独诱导骨组织形成的局部生长因子。目前有关动脉粥 样硬化及血管钙化中 BMP-2 作用机制的研究日益增多。本文就近年 BMP-2 诱导动脉钙化 (ar ter ial calcification ，AC) 的相关研究进展作一综述。 [关键词] 骨形态发生蛋白 (BMP-2) ；血管钙化；microRNA ；细胞凋亡；蛋白C-羧基谷氨酸基质蛋白 (MGP) New progress between bone morphophonemic protein 2 (BMP-2) and vascular calcification LI Lan, LIU Jianghua, ZU Xuyu, WU Ying (First Affiliated Hospital of Nanhua University, Hengyang Hunan 421001, China) Abstract Vascular calcification is an initiative, preventable, reversible and highly regulated processes as same as osteoblasts biological. Bone morphogenetic proteins (bone morphogenetic proteins, BMPs) families are members of transforming growth factor β (TGF-β) super family, because the characteristics of induced bone formation has named. Now, more than 30 species have been found, BMP-2 is a kind of local growth factor which is the only one can induce bone formation alone. Current research about the mechanism of BMP-2 in atherosclerosis and vascular calcification is increasing. In this