广金钱草、木香对犬胆囊运动及血浆CCK含量影响的实验研究.pdfVIP

2008年第26卷第4期 四 川 中 医 Vo1．26，No．4，2008 Journal of Siehuan of Traditional Chinese Medicine · 31 · 广 金 钱 草 、．木 香 对 犬 胆 囊 运 动 及 ．tats CCK含 量 影 响 的 实 验 研 究 刘敬军 郑长青 周 卓 胡刚正 1．大连市中心医院 (辽宁 大连 116000) 2．中国医科大学 (辽宁 沈阳 110001) 摘要：目的：探讨广金钱草和木香对犬胆囊运动的影响及其机制。方法：用B超测量灌服单味中药前后犬胆囊的 大小，并通过放免法测血浆中灌服中药前后胆囊收缩素 (Cholecystokinin，CCK)的含量。结果：犬胆囊在灌服广金钱 草后胆囊明显收缩，CCK明显升高，并且两者之间呈显著负相关。犬胆囊在服木香后胆囊明显收缩，血浆CCK无明 显改变。结论：灌服广金钱草可使犬胆囊明显收缩，此作用可能是通过增加犬血浆中CCK含量来实现的。木香可使 犬胆囊明显收缩，但对CCK无明显影响。 关键词：广金钱草 木香 胆囊大小 胆囊收缩素 中图分类号：R285 文献标识码：A 文章编号：1000—3649(2008)04—0031—02 The Influence of Herba Lysimachiare and Radix Aucklandiae on the Movement of Dog Gallbladder and Its Plasma CCK Value ／Liu 洳 ／／The Dalian Central hospital(Dalian Liaoning 116000。China) Abstract objective：the aim is to study the influence of Herba Lysimaehiare and Radix Aueklandiae on dog gallbladder and its mechanism．Methods：The size of the gallbladder before and after administration was determined by B ultrasound。and the eholecys． tokinin(CCK)value in plasma was determined by radio-immunity assay．Results：The size of the gallbladder was significantly de— creased after the administration of Herba Lysimaehiare，according to this，its plasma CCK was markedly increased；on the other hand。 the size of the gallbladder was also significantly decreased after the administration of Radix Aueklandiae，with no change in CCK、Con． clusion：Herba Lysimachiare can decrease the size of the gallbladder by increasing the plasma CCK value，at the same time，Radix Aueklandiae can also decrease the size of gallbladder but has no significant effect on CCK、 Key words：Herba Lysimachiare。Radix Aucklandiae。the size of gallbladder。eholeeystokinin 胆石症是我国的常见病，患病率高达 8％一13％。 1．3 仪 器、试剂 Aloka SSD．210SX超声诊断仪 ，探 口服药物 (特别是 中药)排 出胆囊 、胆