地诺前列酮用于足月妊娠促宫颈成熟及引产的临床观察.pdfVIP

3 · 373· 地诺前列酮用于足月妊娠促宫颈成熟及引产的临床观察 张晓静 赵 华 赖 虹 黎凤彩 张 铬 梁丽笙 李 倩 广州中医药大学附属南海妇产儿童医院产科 528200 中国图书分类号 11719．3 文献标识码 B 文章编号 1001-4411(2O惦)o3073413 【摘 要】 目的：探讨地诺前列酮一控释前列腺E：栓剂用于足月妊娠促宫颈成熟的有效性及安全性。方法：将135例足 月妊娠孕妇随机分为两组，研究组90例，在阴道后穹隆放置地诺前列酮1枚 (1O mg)；对照组45例，给予蒂洛安200 ms／d静 推3天，促宫颈成熟，3天后用2．5 u催产素静滴，比较两组产妇的宫颈Bishop评分、分娩情况和引产成功率。结果：研究组促 宫颈成熟效果明显优于对照组 (P0．O1)，I临产发动时间、破膜时间均短于对照组 (P0．01)，引产成功率高于对照组 (P 0．O1)，剖宫产率低于对照组 (P0．05)；两组I临产至分娩时间、产后出血、胎儿窘迫及新生儿窒息无明显差异 (P0．05)。 结论：地诺前列酮能有效的促宫颈成熟及引产，可安全的用于临床。 【关键词】 地诺前列酮 促宫颈成熟 引产 The clinical observation of applying dinoprostone suppositories to ripen the cervix and induce labor in term pregnancies ZHANG Xiao—Jing，ZHAO Hua， ，Hong，et a1．Nanhai Affiliated Maternity and ChildrenHospital ofGuangzhou U- nive~ity of Traditional Chinese，Guangzhou 528200。China [Abstract] Objective：To evaluate the efficacy and safety of continuously released dinoprostone suppositories—prostaglandin E2 pessary for cervical repening and inducation labor in term pregnancies．Methods： 135 cases term pregnant women were randomly divided into two groups，90 cases as study group received a dinoprostone suppositories pessary(10mg)inserting into vaginal，while 45 cases as control group received transvenous injecting sodium prasterone sulfate of 200 ms／d．After 3 days both groups received transvenous dripping 2．5 U OX· ytocin．The cervical mature(by Bishop scroring)，labor condition and the achievement ratio of induction delivery were compared between two groups．Results：The efficacy of ripening cervix in study group Was obviously superior to that in control group(P0．O1)．Time to la· bor starting and membrane rupture in study group were both shorter than that in control group(P0．01)．Achievement ratio of induction delivery in study group was higher than that in control group(P0．05)．Cesarean section rate in study group Was lower than th