05大环内酯类（Large cyclic lactone）.docVIP

05大环内酯类（Large cyclic lactone） Doctor pharmacopoeia - antibacterial drug - macrocyclic lactone erythromycin Erythromycin (Ilotycin, Erycin) [function and purpose] This product is a large ring lactone class antibiotic, antibacterial spectrum similar to penicillin, mainly for gram positive bacteria such as s. aureus bacteria, hemolytic streptococcus, pneumococcus, diphtheria bacillus, bacillus anthracis and spindle of bacillus coli, etc, all have strong antibacterial effect. For the gram-negative bacteria such as meningococcal, gonorrhoeae, bacillus pertussis, influenza bacillus, brucella, some dysentery bacillus and e. coli, etc. The characteristic is the strain that develops resistance to penicillin, this product is sensitive. Mechanism primarily with RNA 50 s ribosomal subunit, the combination of inhibitory peptides acyltransferase, affect the displacement process of RNA that ribosome, hinder peptide growth, inhibition of bacterial protein synthesis, bacteriostatic agent. It is mainly used for the infection of penicillin and the aureus infection. Also used for hemolytic streptococcus and respiratory tract caused by pneumococcus, legionella pneumonia, mycoplasma pneumonia, skin and soft tissue infection, in addition, patients with diphtheria, use this product and diphtheria antitoxin is curative effect is remarkable. [dosage and usage] Erythromycin tablet (intestinal sol), oral, adult 1g ~ 2g/day; Children daily 30mg ~ 50mg/kg, 3-4 times. Static or static drops can be found in Erythromycin Lactobionate, adult 1g ~ 2g/day; Childrens daily 20mg ~ 30mg/kg, 2 ~ 3 times. 【 side effect 】 1 gastrointestinal reactions can be related to nausea, vomiting, abdominal pain and diarrhea. Allergic reaction, can have urticaria and medicinal heat. 3 can cause liver damage, such as serum alanine aminotransferase increased, jaundice, etc. 4 static or static drops lactose acid erythromycin can cause thrombotic phlebitis, and there is more possibility of static injection. Muscle inject