鱼腥草热敏凝胶滴眼液的药效学研究.pdfVIP

· 药物研究 · 2008年7月第5卷第19期 鱼腥草热敏凝胶滴眼液的药效学研究 郭 彬 ，刘志承 ，魏俊婷 ，魏 云 (1．广东省深圳市中医院药剂科，广东深圳 518033；2．湖南医药工业研究所，湖南长沙 410007) [摘要】目的：研究鱼腥草热敏凝胶滴眼液(HTGE)对细菌性感染兔眼的药效学。方法：用3种质控致病菌感染兔眼， 再进行鱼腥草热敏凝胶滴眼液(HTGE)、鱼腥草滴眼液(HED)、氧氟沙星滴眼液(OED)的对比治疗，评价其药效学， 包括治疗后细菌转阴(清除)率和治愈率。结果：HTGE(2次／d)、HED(5次／d)、OED(5次／d)的细菌转阴(清除)率和治 愈率分别为91．5％和93．2％、74．6％和83．1％、91．5％和86．4％。与OED组比较，HTGE组无明显差异(P0．05)，与HED 组比较则有明显差异(P0．05)。结论：HTGE在感染兔眼药效学试验中疗效明显，可供临床使用。 『关键词1鱼腥草热敏凝胶滴眼液(HTGE)；细菌性感染；家兔眼；药效学研究 【中图分类号】R965 [文献标识码】A [文章编号】1673—7210(2008)07(a)一32—02 Pharmacodynamic study 0f Houttuynia Thermosensitive Gel Eyedrop GUO Bin1,LIU Zhi—chen~,WE1 Jun—tinf,WEl YtⅡ f1．Department of Pharmacy，Shenzhen Hospital of TCM，Shenzhen 518033，China；2．Hunan Pharmaceutical Industrial Research Institute，Changsha 410007，China) 【Abstract]Objective：To study the pharmacodynamic effect of Houttuynia Thermosensitive Gel Eyedrop (HTGE)on the rabbits eyes with bacterial infections．Methods-To infect rabbits eyes with 3 control bacteria,then these rabbits were treat— ed by HrIlGE，Houttuynia Eyedrop(HED)and Ofloxacin Eyedrop(OED)．The pharmacodynamic evaluation included eredica— tion (clearance)rates and cure rates after treated．Results：The bacterial eredication clearance)rates and cure rates were 91．5％and 93．2％for HTSG(2 times／d)，74．6％and 83．1％for HED(5 times／d)，91．5％and 86．4％for OED f5 times／d)re— spectively．Compared with OED，HTGE had no significant difference(P0．05)；compared with HED，HTGE had significant diffefence fP0．05)．Conclusion：The efficacy of HTGE iS good for the bacterial infection rabbits eyes，and HTGE Can be used for the clinical treatment． 【Key words]Houttuynia Thermosensitive Gel Eyedrop(HTGE)；Bacterial infection；Rabbit S eyes；Pharmacodynamic study 我院根据临床需要，多年常规配制鱼腥草滴眼液，