自体表皮移植治疗稳定期白癜风三种受皮区处理方法临床应用评价.docVIP

自体表皮移植治疗稳定期白癜风三种受皮区处理方法临床应用评价[摘要]目的 评价3种受皮区处理方法在自体表皮移植治疗稳定期白癜风的临床应用效果。方法 3组（每组40例）接受自体表皮移植治疗的稳定期白癜风患者，供皮区采用负压吸疱法制备表皮，受皮区则分别采用负压吸疱法(A组）、机械磨削法（B组）和超脉冲CO2激光磨削法（C组）处理。治疗8周后观察疗效，对治疗效果进行统计学分析。结果 A、B、C3组的治疗有效率分别为97.2%，93.7%和95.5%，3组间差异无统计学意义（P0.05）。结论 在3组的治疗有效率无统计学差异的基础上，临床操作过程中负压吸疱法、机械磨削法各有其局限性，而超脉冲CO2激光磨削法处理受皮区因为操作灵活、快捷和精确，显示出优越性。? [关键词] 白癜风；自体表皮移植；超脉冲CO2激光；负压吸疱；机械磨削? [中图分类号] R758.41[文献标识码] A [文章编号] 1671-7562（2007）02-0133-03?? Evaluation of the clinical effect of three transplantation bed preparation methods? in treatment of stable vitiligo with autologous epidermal grafting?? ZHANG Jing-dong,WANG Ping,WANG Fei,CHEN Yu-xia,QI Cui-feng (Department of Dermatology,Zhongda Hospital,Southeast University,Nanjing 210009,China)?? Abstract:Objective To evaluate the clinical effect of three transplantation bed preparation methods in treatment of stable vitiligo with autologous epidermal grafting.Methods The transplantation beds of three groups(each 40 cases) were prepared respectively by negative pressure suction(group A),instrument abration(group B) and ultrapulse CO2 laser resurfacing(group C).Epidermal grafts were harvested with negative pressure suction.The curative effect was evaluated 8 weeks later.The effective rates of three groups were analysed statistically.Results There was no statistically significant differences in the effective rates of three groups(group A 97.2%，group B 93.7%,group C 95.5%，P0.05).Conclusion Because of the restriction of negative pressure suction and instrument abration in preparating transplantation beds,ultrapulse CO2 laser resurfacing shows its dominance by reason of its easy performance and high precision.? Key words:vitiligo;autologous epidermal grafting;ultrapulse CO2 laser;negative pressure suction;instrument abration? (Modern Medical Journal,2007,35:133-135)?? 自体表皮移植治疗白癜风已在临床逐渐推广应用，疗效确切。自体表皮移植治疗操作过程中供皮区大多采用负压吸疱制备表皮片，受皮区准备方法则有多种。我科自1998年10月至2006年5月采用自体表皮移植治疗稳定期白癜风，先后采用负压吸疱、皮肤机械磨削及超脉冲CO2激光磨削3种方法准备受皮区，在378例患者中随机选