金芪降糖片对2型糖尿病尿微量白蛋白排泄率影响.docVIP

金芪降糖片对2型糖尿病尿微量白蛋白排泄率影响【摘要】 目的 探讨金芪降糖片对2型糖尿病患者尿微量白蛋白排泄率(UAER)的影响。方法 选择2型糖尿病经单纯饮食治疗血糖控制失败并伴早期糖尿病肾病29例随机给以金芪降糖片或二甲双胍治疗6个月，比较两组间UAER的差别。结果 治疗前两组间UAER无明显差别(65．9±16．1)vs（63．6±18．6）μg/min,P=0．2693。治疗六个月时金芪降糖片组UAER(43．7±11．5)μg/min较二甲双胍组(56．6±12．0)μg/min明显降低(P=0．0065)。结论 金芪降糖片除降血糖作用外还具有潜在的降尿微量白蛋白作用，有价值进一步探讨。? 【关键词】2型糖尿病；尿微量白蛋白排泄率；金芪降糖片?? The effect of Jinqi hypoglycemic tablet on urine albumer excretion rate in patients with type 2 diabetes SHI Ying, HAN Chun-sheng.Department of Nephrology Third Affiliated Hospital of Heilongjiang Medical College, Qiqihaer, 161000, China ? 【Abstract】 Objective To investigate the effect of Jinqi hypoglycemic tablet on urine albumer excretion rate(UAER)in patients with type 2 diabetes． MethodsTwenty nine patients with type 2 diabetes in plasma glucose poorly controlled with diet treatment accompanied by early diabetic nephropathy were randomly treated with Jinqi hypoglycemic tablet and metformin for 6 months, and were evaluated by differences of UAER between Jinqi hypoglycemic tablet and metformin group． ResultsThere was no significant difference in UAER between the two groups before treatment(65．9±16．1vs63．6±18．6 μg/min,P=0．2693)． By 6 months of treatment, UAER in Jinqi hypoglycemic tablet group(43．7±11．5 μg/min) was significantly lower(P=0．0065) than etformin group(56．6±12．0 μg/min)． ConclusionThere is a potential effect of reducing UAER in Jiqi hypoglycemic tablet excluded glucose lowering effect so it is valuable to further study on．? 【Key words】Type 2 diabetes mellitus; Urine albumer excretion rate; Jinqi hypoglycemic tablet ? 笔者在临床中发现长期服用金芪降糖片的2型糖尿病患者尿蛋白减少，因此选择一些服用和未服用金芪降糖片2型糖尿病早期肾病变患者对照观察治疗前后尿蛋白的变化。 ? 1 对象和方法? 1．1 对象来源 2007年1月至2007年12月在齐齐哈尔医学院第三附属医院内科门诊患者收集入选对象。? 1．2 入选和排除标准 选择《中国糖尿病防治指南》[1]标准确诊的2型糖尿病经单纯饮食治疗失败并伴早期糖尿病肾病(UAER:20～200 μg/min)不伴高血压患者。受试期间出现糖尿病酮症、泌尿系感染、上呼吸道感染、发热等患者除外。? 1．3 治疗方法 一经入选随机给以金芪降糖片治疗(8～10片,3次/d)或二甲双胍片(0．25～0．5 g,3次/d)治疗。? 1．4 研究终点 持续治疗3个月测糖化血红蛋白(HbA1c)和UAER。到6个月时，再次测HbA1c和UAER