恶性组织细胞病（Malignant histiocytic disease）.docVIP

恶性组织细胞病（Malignant histiocytic disease） Malignant histiocytosis Malignant histiocytosis (MH) is a malignant disease of abnormal proliferation of tissue cells and precursor cells, mainly involving the lymphatic and hematopoietic organs. Clinical have high fever, liver, spleen, lymph nodes, pancytopenia and progressive failure. (a) pathological abnormal tissue cell infiltration is the basic characteristic of the disease, involving a wide range, in addition to the common liver, spleen, bone marrow and lymph nodes also can invade and non hematopoietic tissues, such as lung, skin, kidney, gastrointestinal muscularis mucosa and serosa. The main pathological changes for evil group shaped cells showed patchy infiltration, sometimes also can form miliary granuloma, or nodular lesions, generally do not form a mass either primary or metastatic lesions, there is obvious difference with solid tumor. In the above organs not all are involved, such as disease, its distribution is not uniform. (two) the clinical manifestations of fever and symptoms led. Most of the irregular fever, a few of which is low or moderate fever. Fever often persistent, and gradually increased with the progression of the disease, but even shivering with chills. 1. hematopoietic organ involvement in the reduced blood cells caused by anemia, infection and bleeding. The liver, spleen and lymph node tissue due to cell infiltration and gradually enlarged. The swell of spleen was generally below the costal margin of 3 ~ 5cm, the texture from medium to hard, can have tenderness, occasional pain. Soft to hepatomegaly, maximum rib 3 ~ 5cm. Lymph nodes for soy bean size, with the most common neck and axillary, a manifestation of abdominal block. The late course of jaundice, mainly related to liver damage, a few lines of hepatic lymph nodes caused by bile duct oppression. 2. non hematopoietic organ involvement in the pulmonary lesions are rare, patients with cough and hemoptysis and respiratory failure, X chest showed