肿瘤恶病质骨骼肌消耗机制的研究进展.pdfVIP

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肿瘤恶病质骨骼肌消耗机制的研究进展.pdf

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肿瘤恶病质骨骼肌消耗机制的研究进展

World Journal of Cancer Research 世界肿瘤研究, 2016, 6(4), 43-48 Published Online October 2016 in Hans. /journal/wjcr /10.12677/wjcr.2016.64008 Progress in Mechanism of Muscle Wasting in Cachexia * # Yu Zhou , Xiaoyun Zhu, Jie Wu Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing th th th Received: Nov. 26 , 2016; accepted: Dec. 16 , 2016; published: Dec. 20 , 2016 Copyright © 2016 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Open Access Abstract Objective: This article summarized the progress in study of muscle wasting in cancer cachexia. It inquired into the mechanism and up-stream signaling cascades of muscle wasting in cancer ca- chexia from ubiquitin-proteasome and autophagy-lysosomal systems perspective, laying the foundation of study in prophylaxis and treatment of cancer cachexia. Methods: Using Medline to search literature about cancer cachexia and muscle wasting from Jan. 1971 to Jun. 2013, and get- ting 898 pieces of literature in total. Inclusion Criteria: 1) relevant literature in latest decade; 2) related to the signaling cascades and effective factors of muscle wasting. Exclusion Criteria: 1) muscle wasting irrelated to cancer cachexia; 2) signaling cascades and effective factors irrelated to UPS or ALS. Literatures meeting inclusion criteria are 87 pieces, and literatures eliminated ac- cording to exclusion criteria are 31 pieces. Literatures analyzed eventually are 25 pieces. Results: Multiple factors