伤科接骨片对家兔骨折愈合过程中血钙影响.docVIP

伤科接骨片对家兔骨折愈合过程中血钙影响[摘要] 目的 观察伤科接骨片对骨折愈合过程中血钙的影响。方法 将40只实验用家兔随机分为伤科接骨片组和空白组, 用10%水合氯醛3mL/kg静脉麻醉,于左前肢桡骨中段造成3～5mm骨折缺损模型, 术后按组分别给予伤科接骨片和蒸馏水灌胃,术后第2、4、 6周分别检测血Ca。结果伤科接骨片可调节血Ca水平,与空白组相比差异有统计学意义（P ＜0.05）。结论 伤科接骨片能够加快血肿机化的吸收和骨痂形成速度,调节血Ca水平,加速钙盐沉积，对骨折的愈合和修复有明显的促进作用。 [关键词]伤科接骨片;家兔;骨折愈合；血钙水平 [中图分类号]R683[文献标识码] A [文章编号] 1673-9701（2011）19-16-02 Effect of Shangkejiegu Tableton Blood Ca2+ Level in Fracture Healing Rabbits JIA Rui1 LIUHuimei2 1. Linyin Road Community Service Center, Baotou Iron and Steel Group Staff and Worker ‘ Hospital，Baotou014010, China; 2. Zhangjiaying Branch, Baotou Iron and Steel Group Staff and Worker ‘ Hospital, Baotou 014012, China [Abstract] ObjectiveTo study the effect of Shangkejiegu Tablet on rabbits blood Ca level in fracture healing. Methods The fracture model was established by making 3～5mm defect in the middle of radius after the general anaesthesia by the C2H3Cl3O2 liquor of 10%,40 rabbits were randomly divided into two groups as follows:the Shangkejiegu tablet（SKJGT）group ,and the blank control group,which were given orally with SKJGT and distilled water respectively. The examination were made at 2、4、6 weeks after operation; blood Ca level were tested at 2、4、6 weeks after operation. Results The examination were showed that SKJGT can adjust the blood Ca level（P＜0.05）. Conclusion SKJGT can adjust the blood Ca level， This trail prove that the SKJGT can accelerate function in fracture healing and repairing（P＜0.05）. [Key words] Shangkejiegu tablet; Rabbit; Fracture healing; The blood Ca level 骨折就是骨的完整性和连续性的中断,是临床最多见的外伤性疾患。骨折愈合是指骨折断端间的组织修复反应，这种反应表现为愈合反应，最终结局是恢复骨的正常结构与功能[1]。本文观察伤科接骨片对骨折愈合过程中血钙水平的影响，探索其作用机制, 为进一步研究提供依据。 1#8195;资料与方法 1.1#8195;实验材料 1.1.1#8195;实验动物#8195;健康5月龄新西兰大耳白家兔40只,雌雄各半。体重（2.0～2.5）kg/只,由包头医学院实验动物中心提供。控制室温为20 ～ 25℃ , 湿度为 50%～ 70% 。动物适应性饲养1周后开始实验。 1.1.2#8195;实验药物#8195;伤科接骨片（批号:200902136, 厂家：大连美罗中药厂有限公司）。水合氯醛、青霉素、500mL生理盐水（批号：M0911092 厂家：四川科伦药业有限公司）。 1.1.3#8195;实验器材#8195;兔架、托盘式扭力天平、兔灌胃管、锯条、外科手术器械、注射器