美卡素联合氢氯噻嗪治疗原发性高血压疗效观察.docVIP

美卡素联合氢氯噻嗪治疗原发性高血压疗效观察[摘要]目的 观察美卡素(替米沙坦)与氢氯噻嗪联合治疗原发性高血压的疗效。方法 75例原发性高血压患者随机分为治疗组和对照组。治疗组40例,患者每日服用80mg美卡素及12.5mg氢氯噻嗪,对照组35例,患者每日服用美卡素80mg,试验共8周。结果 (1)与治疗前相比,治疗组及对照组患者血压均有下降,但联合治疗组疗效更显著,总有效率达95%,而对照组总有效率为88.5%,两组间比较有显著性差异。(2)不良反应:治疗前后两组间血糖、血脂、尿酸等比较均无显著性差异。结论 美卡素与氢氯噻嗪联合治疗原发性高血压病疗效显著,且安全性良好。 [关键词]高血压;美卡素(替米沙坦);氢氯噻嗪;联合治疗 [中图分类号] R544.1[文献标识码] A [文章编号] 1673-9701(2010)06-151-02 Micardis Combined with Hydrochlorothiazide in Treatment of Essential Hypertension:An Observation of Curative Efficacy YIN Xiaokan1ZHU Xianlin2 1. Jiangxin Township Hospital,Zhenjiang 212144,China;2 The Staff and Worker’ Hospital of Jiangsu University,Zhenjiang 212013,China [Abstract]Objective To observe the curative efficacy of micardis(telmisartan)plus hydrochlorothiazide for essential hypertension.Methods Seventy-five cases of essential hypertension were randomly divided into treatment group(40 cases) and control group(35 cases). The treatment group was treated with 80mg telmisartan plus 12.5mg hydrochlorothiazide daily for 8 weeks,and the control group was treated with 80mg telmisartan alone daily for 8 weeks. Results The systolic blood pressure(SBP) and diastolic blood pressure(DBP) were improved in both groups after 8-week therapy compared with pre-therapy,and however,the treatment group showed more significant improvement than the control group,with the total effective rate of the treatment group being 95% and that of the control group being 88.5%. There was no significant difference in fasting blood glucose(FBG), triglycerides(TG) and total cholesterol(TC) between the two groups before and after treatment. Conclusion Telmisartan combined with hydrochlorothiazide is effective and safe in the treatment of esential hypertension. [Key words]Hypertension;Micardis(telmisartan);Hydrochlorothiazide;Combination therapy 高血压是一种世界性的常见疾病,全世界人群高血压的患病率高达10%～20%,且有逐年增高、年轻化趋势。高血压对人类最大的危害是能导致病人心脏、脑和肾脏等重要器官一系列严重病变,是危害人类健康的重要疾病[1]。我院自2008年6月～2009年6月应用美卡素和小剂量氢氯噻嗪治疗原发性轻、中度高血压40例,取得了显著疗效,现总结