轮状病毒肠炎儿童血锌水平变化及其及体液免疫相关性探究.docVIP

轮状病毒肠炎儿童血锌水平变化及其及体液免疫相关性探究[摘要] 目的 探讨轮状病毒肠炎儿童血清锌水平变化及其与体液免疫的相关性。 方法 对96例轮状病毒肠炎患儿（疾病组）及138例同龄健康儿童（对照组）的血清免疫球蛋白及锌水平进行比较，并分析血清锌及免疫球蛋白水平的变化在疾病组中的相关性。 结果 轮状病毒肠炎患儿血清锌水平及IgA、IgG水平明显低于对照组（P ＜ 0.05），同时疾病组中血清锌与IgA、IgG水平之间存在相关性（r = 0.78、0.69，均P ＜ 0.05）。 结论 轮状病毒肠炎儿童免疫功能的降低与血清锌水平的下降存在一定的相关性。 [关键词] 轮状病毒；肠炎；锌；体液免疫 [中图分类号] R392.7 [文献标识码] B [文章编号] 1673-7210（2012）01（c）-0142-02 The study on the change of Serum zinc in children with rotavirus enteritis and the correlation with humoral immunity LIU Junfeng GAO Feng WANG Dongying HUANG Junhua REN Ruifeng Department of Pediatrics， the General Hospital of Huabei Oil Field， Hebei Province, Renqiu 062552, China [Abstract] Objective To explore the change of serum zinc level in children with rotavirus enteritis and the correlation with humoral immunity. Methods 96 cases of children with rotavirus enteritis and 138 health children of the same age were determined as disease group or control group. The humoral immunity and serum zinc level in the two groups were compared. And then， the correlation between the change of serum zinc level and humoral immunity in disease group was analyzed. Results The serum zinc and immunoglobulin A， immunoglobulin G were lower significantly in children with rotavirus enteritis than those in control group (P ＜ 0.05), and there was a correlation between serum zinc and immunoglobulin A or immunoglobulin G in disease group (r = 0.78, 0.69, all P ＜ 0.05). Conclusion The decrease of immunologic function in children with rotavirus enteritis is associated with the decrease of serum zinc. [Key words] Rotavirus; Enteritis; Zinc; Humoral immunity 轮状病毒是引起婴幼儿腹泻病的主要病原体[1-2]。大量的研究显示，患轮状病毒肠炎的儿童，其血锌水平较正常儿童相比存在不同程度的降低，但其在病理生理过程中所发挥的作用及其因果关系尚无定论。本研究对患轮状病毒肠炎儿童的血锌及体液免疫水平进行检测，并进一步探讨二者的相关性。 1 资料与方法 1.1 一般资料 选取我院儿科2010年9月～2011年2月收治的轮状病毒肠炎婴幼儿96例作为疾病组，其中，男54例，女42例；年龄6个月～3岁；病程1～2 d。同时选取于我院行健康体检且近1个月无感染史的138例儿童为健康对照组。两组一般资料比较，差异无统计学意义（P 0.05），具有可比性。 1.2 检测方法 两组儿童于清晨空腹采集静脉血5 mL，离心后收集血清应用北京博晖5100型原子吸收光谱仪及配