雌、孕激素及促性腺激素水平测定对于绝经后妇女子宫内膜异常病变筛查临床探究.docVIP

雌、孕激素及促性腺激素水平测定对于绝经后妇女子宫内膜异常病变筛查临床探究【摘 要】 目的:探讨性激素水平测定对于筛查绝经后妇女子宫内膜病变的意义。方法：选取我院门诊有充分手术指征的绝经后流血的患者，空腹时采肘静脉血3ml采用放射免疫RIA法测定性激素水平，并行分段诊刮，任何程度的子宫内膜增殖或增生均视为异常子宫内膜。结果：绝经后妇女子宫内膜异常病变患者的雌激素水平明显高于正常绝经妇女（P0.05），尤其子宫内膜癌患者及子宫内膜不典型增生患者体内雌激素水平较正常绝经妇女显著增高，P0.01，且前两者之间亦有明显差异（P0.05）。结论：绝经后妇女阴道流血不能作为子宫内膜异常病变筛查的单一指标，对绝经后妇女常规进行性激素检测可作为子宫内膜异常病变的筛查方法之一。 【关键词】 性激素; 绝经后妇女； 子宫内膜异常病变 Level of estrogen, progesterone and HCG in the screening for?endometrial disorders among menopausal females LI Mingxun, PIAO jindan, ZHANG Ming, XU Rongchun Department of Obstetrics and Gynecology, General Hospital of Daqin Petroleum Company 【Abstract】 Objectives: To discuss about the significance of the determination of estrogen, progesterone and HCG level in the screening for endometrial disorders among menopausal females. Methods: Patients in our outpatient clinic were selected who were found bleeding after menopause and showed obvious operation index. Venous blood 3ml was drawn from these patients with empty stomach to detect the level of sex hormones by radioimmunoassay method. Scraping was made on various segments to determine endometrial disorders which include any kinds of endometrial proliferation and hyperplasia. Results: The estrogen level of endometrial disordered menopausal patients was significantly higher than that of the normal menopausal females (P0.05). Particularly, estrogen level of patients with endometrial neoplasia and non-typical hyperplasia was much significantly higher than that of normal females(P0.01). Conclusion: vaginal bleeding can’t be taken as the only index for screening of endometrial disorders among menopausal females, while regular determination of sex hormone levels can better serve this function. 【Key words】 sex hormone; menopausal females; endometrial disorders 在妇科恶性肿瘤中，卵巢癌发病率最高，但子宫内膜癌的发病率逐年上升。据报道，我国每年新患病人数为15900人，占女性恶性肿瘤的3%，引起各界人士的关注。宫颈癌和子宫内膜癌若能早期诊断、早期治疗，可达到临床治愈，减少复发，预后良好；若错过癌症早期阶段，则可能导致癌症转移，死亡率高，预后不良，因此早期发现、早期治疗成为目前医学界关注的焦点。目前关于子宫内膜癌尚未有确实的检测指标可提示癌症发生