基于低频振幅算法的难治性癫痫发作间期静息态功能磁共振成像研究 .doc

基于低频振幅算法的难治性癫痫发作间期静息态功能磁共振成像研究 李陈渝1，方维东2，王学峰1（400016 重庆，重庆医科大学附属第一医院：神经内科1；放射科2) [摘要]目的 采用功能磁共振成像（fMRI）探讨难治性癫痫患者发作间期脑功能的改变。方法 对难治性癫痫患者和健康对照的功能磁共振数据均采用低频振荡振幅（ampltitude of low frequency fluction，ALFF）算法分别进行处理，计算并对比难治性癫痫组相比健康对照组ALFF改变的脑区，分析ALFF改变脑区与病程的相关性。结果 静息状态下难治性癫痫组与对照组相比ALFF值增强的脑区主要有中脑、桥脑、尾状核、额下回及双侧海马旁回、海马等部位；ALFF值减弱的脑区主要有双侧额叶、右侧颞上回、扣带回后部及相邻的楔前叶，且右侧颞中回的ALFF值与病程呈负相关（r=-0.71，P0.05）。结论 难治性癫痫患者发作间期存在广泛的脑功能异常，且与癫痫病程相关。ALFF有助于揭示难治性癫痫潜在的病理生理机制。 [关键词] 低频振幅；难治性癫痫；功能磁共振成像 [中图法分类号] [文献标志码]A Study of amplitude of low frequency fluctuation in interictal drug refractory epilepsy using resting-state FunctionMRI Li Chenyu1, Fang Weidong2, Wang Xuefeng1（Department of Neurology1, Department of Radiology2, First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China） [Abstract]ObjectiveToinvestigate the interictal of brain function in patients with drug refractory epilepsy (DRE) in resting state with blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI).MethodsDate of fMRI in all subjects were calculated and compared using the method of ampltitude of low frequency fluctuation(ALFF), the correlation between ALFF and disease duration wasanalysed. ResultsDRE showed significantly strengthened ALFF in midbrain, pons, caudate, inferior frontal gyrus and bilateralparahippocampalgyrus, hippocampus compared with normal controls;Weakened ALFF were found in bilateral frontal lobe, right superior temporal gyrus, anterior cingutate and precuneus, a correlation analysis of ALFF at each voxel in the whole brain against the disease duration in the epilepsy with drug refractory revealed a significantly negative correlation in right middle temporal gyrus (r=-0.71, P0.05).ConclusionThe brain function was widespread abnormalities in DRE compared with the normal controls. ALFF contributes to explain the potential pathophysiological mechanism of t DRE. [Key words]ALFF; drug refractory epilepsy; functional MRI(fMRI) Supported by the N