转化生长因子与组织创伤修复综述刘凯.pdfVIP

1999 13 5 · 283· β 刘　凯　钱云良　范志宏 　　【　】　　　β( T GF-β) 。 　 - , - 、 - T GFβ T GF β T GF β 。　T GF-β ,, T GF-β, - 、。　 - T GFβ T GFβ 。 【】　　β　　　　 / REVIEW ON TRANSFORMING GROWTH FACTORβ AND REPAIR OF TISSUE INJURY L IU , - , - . , 9 Kai QIAN Yun liang F AN Zhi hong Dep artment of Plastic Surgery Shanghai th Peop le s Hosp ital , Shanghai Secon Me ical University . Shanghai , P .R. China 200011 【Abstract】　　 Objective　 T o review the progress of the relation betw een transforming ( - ) . 　 - grow th fa tor β T GFβ and repair of tissue injury Meth ds The re ent arti les about T GF β and tissue re onstru tion w ere extensively reviewed. The gene identifi ation, produ tion, a tiva- tion of T GF-β and its role in the repair ourse of tissue injury w ere investigated. Results　 T GF-β belongs to a family of multifun tional polypeptides, its gene stru ture is highly onservative. - . Many animal models about T GF β and tissue injury have been established The resear h mainly fo- uses on the lassifi ation, distribution of T GF-β re eptors and their signal pathw ay. C nclusi n T GF-β plays an important roles in the regulation of repair of tissue injury. 【 】　　 　　 　　 Key w rds Transforming grow th fa torβ Tissue injury Rapair 　　β( transforming grow th 1q41, T GF-β 70