comt基因多态性与子宫内膜异位症和子宫腺肌-河北师范大学学报.pdfVIP

35 / 3 / 河北师范大学学报/ / Vol. 35 No. 3 2011 5 JOURNALOFHEBEI NORMAL UNIVERSITY/ Natural Science Edition/ May. 2011 COMT 基因多态性与子宫内膜异位症和 子宫腺肌病关系研究 1 2 2 张 峰, 薛素萍 , 曲银娥 ( 1. , 071000; 2. , 063000) : K DNA, (PCRRFLP) 61 (EMs) 59 (Ad ) 65 ( ) , COMT . : 1) G/ G, G/ A,A/ A A ; 2) G/ G G/ A G/ G 0. 629 0. 876 , ., COMT Nla, . : COMT; ; ; : R 711.71 :A : 2011) Study on the Correlation Between Gene Polymorphism of COMT and Endometriosis and Adenomyosis 1 2 2 ZHANG Feng , XU E Suping , QU Yine ( 1.College of Health Vocational T echnical, Hebei University,Hebei Baoding 071000, China; 2. Basic Medical College,Hebei United University, Hebei Tangshan 063000, China) Abstract:To study the correlation between gene polymorphism of CatecholOMethyl transferase ( COMT) and endometriosis ( EMs) and adenomyosis (Ad) , the polymorphism of COMT gene was analyzed by polymerase chain reaction and restriction fragment length polymorphism ( PCRRFLP) method in 61patients with EMs and 59 patients with Ad and 65 healthy controls.There was no significance of the alleles and genotype between EMs group, Ad group and control group.T he relative risk suffered from endometriosis of G/ A and A/ A genotype was 0. 629 and 0. 876 times of the G/ G genotype respectively. There was no correlation between the Nla gene polymorphism of COMT and endometriosis and adenomyosis.T he mechanism of endometriosis and adenomyosis was similar. Key words:COMT; gene polymorphism; endometriosis; ad