外泌体对缺血再灌注器官损伤的保护作用 - 中国修复重建外科杂志.pdf

中国修复重建外科杂志 2017年6月第31卷第6期 • 751 •   ·综 述· 外泌体对缺血再灌注器官损伤的保护作用 黄静兰，康冰瑶，屈艺，母得志 四川大学华西第二医院儿科 出生缺陷与相关妇儿疾病教育部重点实验室（成都   610041 ） 【摘要】   目的    总结外泌体对缺血再灌注器官损伤的保护作用，为其治疗提供新思路。 方法     广泛查阅近 年国内外与外泌体治疗缺血再灌注损伤相关的文献，分析总结其作用机制。 结果    外泌体体积小，存在于血液、 脑脊液、尿液等细胞外液中，能够穿透血脑屏障，可通过多种分子机制对心脏、脑等器官的缺血再灌注损伤起到 保护作用，并且无肝、肾副作用。 结论     外泌体治疗可能成为逆转缺血再灌注器官损伤的新方法，了解外泌体对 缺血再灌注损伤的保护作用及可能机制具有重要意义。 【关键词】  外泌体；缺血再灌注；器官损伤；治疗 Protective effect of exosome on organs after ischemia-reperfusion injury HUANG Jinglan, KANG Bingyao, QU Yi, MU Dezhi Department of Pediatrics, Key Laboratory of Obstetric Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China Corresponding authors: KANG Bingyao, Email: Ïkangbingyao2016@163.com; MU Dezhi, Email: mudz@ 【Abstract 】 Objective    To investigate the protective effect of the exosome on the organ damage induced by ische- mia-reperfusion (I/R) so as to provide a new way for the treatment of I/R damage. Methods    The literature related to the treatment of I/R damage was reviewed and analyzed. Results    The exosome volume is small and it is present in blood, cerebrospinal fluid, and urine, which has the function to cross the blood-brain barrier, and protect the heart, brain and other organs after I/R damage. Conclusion    Exosome is a new material for the treatment of I/R organ injury, and it is important to understand the protective effect and possible mechanism. 【Key words 】 Exosome; ischemia-reperfusion; organ injury; treatment Foundation items:  National Natural Science Foundation of China ; National Basic Research Program of China (2013CB967404, 2012BA