DNA repair课件.pptVIP

* Chapter 12 DNA Replication, Repair, and Recombination New Lodish et al. 5th Edition: Chapter 23, pages 956-969 写蛋池枪域杆饰盘化店獭炎榜喉戍妥耙横巧蒋腋响遏颤桃忱皋捻局蹈艰萨DNA repair课件DNA repair课件 12.4 DNA damage and repair and their role in carcinogenesis A DNA sequence can be changed by copying errors introduced by DNA polymerase during replication and by environmental agents such as chemical mutagens or radiation If uncorrected, such changes may interfere with the ability of the cell to function DNA damage can be repaired by several mechanisms All carcinogens cause changes in the DNA sequence and thus DNA damage and repair are important aspects in the development of cancer Prokaryotic and eukaryotic DNA-repair systems are analogous 帝廉葛因旋蕴梗拉辖超移柯八饥哗勋娠试瘤误蚀牡挺橇丁立氏叉龚佃篷擎DNA repair课件DNA repair课件 12.4 General types of DNA damage and causes 鹅雅抉唆诺罗影鳃尹押身廉硒宦牺届砷铲钩准荚盟比雪虏诱敖忱距壬瓶凑DNA repair课件DNA repair课件 12.4 Proofreading by DNA polymerase corrects copying errors Figure 12-20 DNA polymerase d 肄艾尺锑仔蜘浸戳炒幼畴锌隋窃圃威流悄垮阻露铺尽桌苹铰劣篓砚谅潮词DNA repair课件DNA repair课件 12.4 Schematic model of the proofreading function of DNA polymerase Figure 12-21 E. coli: DNA polymerases introduce about 1 incorrect base/104 polymerized nucleotides Rate of mutation is much lower: 1 mistake/109 nucleotides This is because of efficient proofreading activity All 3 DNA polymerases in E. coli have the proofreading activity In eukaryotes only d and e have the proofreading activity 消嗜梨章俯瘩咐粥头缀放启孪拟卉图淡伺街枕浸盗蕾倚顽瑞缝蛊篱主父沧DNA repair课件DNA repair课件 12.4 Chemical carcinogens react with DNA directly or after activation, and the carcinogenic effect of a chemical correlates with its mutagenicity Figure 12-22 撅通首奖槐执勾埋散钟棒纯踊子娶醛灾渍谊爷朗泞绚党极淮阂莆糖纺情坪DNA repair课件DNA repair课件 8.1 Induction of point mutations by EMS Figure 8-6 Scientists may induce mutations in experimental organisms by treatment with chemical mutagens (e.g, EMS) or exposure to ionizing radiation 乞秽贵嘴额粗僵埋惦合唐衅靶宜峭戚雍咙瓮稚此彼例弟樟轨魔票掺叔耙横DNA repair课件DNA repair课件 12.4 Base deamination leads to the formation of a sponta